Fluorocarbons reduce myocardial ischemic damage after coronary occlusion.
Fluorocarbons reduce myocardial ischemic damage after coronary occlusion.
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碳氟化合物可减少冠状动脉闭塞后的心肌缺血损伤。
DOI：
10.1126/science.7466402
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
ClarkJr,LC
中科院分区：
文献类型：
--
作者：
Glogar,DH;Kloner,RA;Muller,J;DeBoer,LW;Braunwald,E;ClarkJr,LC
左冠状动脉前降支闭塞的开胸麻醉狗呼吸 100% 的氧气，同时放血至血细胞比容为 25%，并注入大约等体积（40 毫升/千克）的碳氟化合物制剂或林格溶液。呼吸室内空气且不接受任何治疗的狗作为对照。经过 6 小时的冠状动脉闭塞后，放血并接受碳氟化合物治疗的动物比接受林格溶液或未治疗的动物出现更小的梗塞。
Open-chest, anesthetized dogs with occlusions of the left anterior descending coronary artery breathed 100 percent oxygen while they were bled to a hematocrit of 25 percent and infused with an approximately equal volume (40 milliliters per kilogram) of fluorocarbon preparation or Ringer solution. Dogs breathing room air and receiving no treatment served as controls. After undergoing 6 hours of coronary occlusion, animals bled and treated with fluorocarbons developed smaller infarctions than those receiving Ringer solution or no treatment.