Topical latanoprost and optic nerve head and retinal circulation in humans.
Topical latanoprost and optic nerve head and retinal circulation in humans.
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DOI：
10.1089/108076801753266785
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发表时间：
2001-10
期刊：
影响因子：
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通讯作者：
Y. Tamaki;M. Nagahara;M. Araie;K. Tomita;S. Sandoh;A. Tomidokoro
中科院分区：
文献类型：
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作者：
Y. Tamaki;M. Nagahara;M. Araie;K. Tomita;S. Sandoh;A. Tomidokoro
本研究的目的是研究单次滴注拉坦前列素对人视神经头(ONH)和视网膜循环的影响。使用激光散斑组织血流分析，在没有可见表面血管的临时ONH部位每0.125秒测量归一化模糊(Nb；组织血流速度的量化指标)。平均测量3个心动周期(Nb(ONH))。彩色多普勒成像(CDI)检测视网膜中央动脉(CRA)的峰值血流速度(PSV)、舒张期血流速度(EDV)、阻力指数(RI)和视网膜中央静脉(CRV)的平均血流速度(MV)。将0.005%拉坦前列素滴眼液滴入11名健康志愿者的一只眼，另一只眼滴入。分别于注药前、注药后45、90、180、270min测量双眼NB(ONH)、CDI参数、眼压(IOP)、血压(BP)、脉率(PR)。在单次滴注拉坦前列素或赋形剂后，在整个实验期内，没有显著的双侧差异。拉坦前列素组滴眼后45~270min的Nb(OnH)与测量前及各时间点的差值(Nb(OnH))显著高于赋形剂组(P=0.0003~0.0156)，重复测量的方差分析也显示双眼之间有显著差异(P<；0.00001)。只接受载体的双眼的BP、PR和NB(ONH)，双眼CRA的PSV、EDV和RI，CRV的MV变化不大。局部滴注拉坦前列素后，ONH的组织血流速度至少暂时增加。尽管增加的机制尚不清楚，但拉坦前列素对人类ONH组织循环的影响可能具有临床意义。
The purpose of the present study was to study the effect of a single instillation of latanoprost on the human optic nerve head (ONH) and retinal circulation. Using laser-speckle tissue blood flow analysis, normalized blur (NB; a quantitative index of tissue blood velocity) was measured every 0.125 sec at a temporal ONH site free of visible surface vessels. Measurements were averaged for 3 cardiac cycles (NB(ONH)). Color Doppler Imaging (CDI) was also used to evaluate peak systolic blood velocity (PSV), endo-diastolic velocity (EDV), and resistive index (RI) in the central retinal artery (CRA) and mean blood velocity (MV) in the central retinal vein (CRV). One drop of 0.005% latanoprost was instilled into one eye and its vehicle into the other in eleven healthy volunteers in a double-blinded manner. Measurements of bilateral NB(ONH), CDI parameters, intraocular pressure (IOP), blood pressure (BP), and pulse rate (PR) were performed before, and 45, 90, 180, and 270 min after instillation. After a single instillation of latanoprost or the vehicle, there was no significant bilateral difference throughout the experimental period. The difference in NB(ONH) between that before and at each time point of measurement (delta NB(ONH)) in the latanoprost-treated eyes was significantly higher between 45 and 270 min after instillation than that in vehicle-treated eyes (P = 0.0003 to 0.0156); ANOVA for repeated measurements also revealed significant difference between both eyes (P < 0.00001). BP, PR, and NB(ONH) in the eye that received only the vehicle, PSV, EDV, and RI in the CRA in both eyes, and MV in the CRV in both eyes changed little. Tissue blood velocity in the ONH increased at least temporarily following a single instillation of topical latanoprost. Although the mechanism of the increase is unclear, the effects of latanoprost on ONH tissue circulation in humans may have clinical implications.