REGRESSION OF PRIMARY GASTRIC LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE TYPE AFTER CURE OF HELICOBACTER-PYLORI INFECTION
REGRESSION OF PRIMARY GASTRIC LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE TYPE AFTER CURE OF HELICOBACTER-PYLORI INFECTION
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DOI：
10.1016/s0140-6736(95)90113-2
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发表时间：
1995-06-24
期刊：
影响因子：
168.9
通讯作者：
STOLTE, M
中科院分区：
文献类型：
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作者：
BAYERDORFFER, E;NEUBAUER, A;STOLTE, M
胃黏膜相关淋巴组织（MALT）型淋巴瘤与幽门螺杆菌感染有关。我们研究了根除幽门螺杆菌感染对MALT淋巴瘤的影响。33例伴有幽门螺杆菌胃炎的原发性胃低度MALT淋巴瘤患者接受奥美拉唑（每日120mg）和阿莫西林（每日2.25g）治疗14天以根除幽门螺杆菌。除了组织学检查外，在治疗前和随访期间还使用聚合酶链反应（PCR）检测单克隆B细胞的增殖情况。所有患者至少接受了两次治疗后的检查，并且在经过第二个疗程治疗后，所有患者的幽门螺杆菌检测均呈阴性。在组织学上，23例（70%）患者显示淋巴瘤完全消退，4例（12%）部分消退。6例（18%）患者在幽门螺杆菌感染治愈后无变化。1例接受了化疗。在5例接受手术治疗的患者中，4例在切除的胃组织学检查中发现为高度B细胞淋巴瘤，1例为高度T细胞淋巴瘤。在接受检查的16例患者中，有13例在幽门螺杆菌感染治愈后PCR显示单克隆B细胞完全消失。在中位随访1年期间，未发生MALT淋巴瘤复发。原发性胃低度MALT淋巴瘤在根除幽门螺杆菌感染后可完全消退。然而，需要更长时间的随访以明确缓解是否持久。
Lymphoma of gastric-mucosa-associated lymphatic tissue (MALT) type has been linked to infection with Helicobacter pylori. We investigated the effect on MALT lymphoma of eradicating H pylori infection.33 patients with primary gastric low-grade MALT lymphoma associated with H pylori gastritis were treated with omeprazole (120 mg daily) and amoxycillin (2 . 25 g daily) for 14 days to eradicate H pylori. In addition to histology, PCR was used to examine proliferation of monoclonal B cells before treatment and during follow-up. All patients had at least two post-treatment examinations, and all became negative for H pylori, 2 after a second treatment course. On histology, 23 (70%) patients showed complete regression and 4 (12%) partial regression of lymphoma. 6 (18%) patients had no change after cure of H pylori infection. 1 was treated with chemotherapy. Of 5 treated surgically, 4 were found to have high-grade B-cell lymphoma on histology of the resected stomach and 1 a high-grade T-cell lymphoma. PCR showed complete disappearance of monoclonal B cells after cure of H pylori infection in 13 of 16 patients investigated. During median follow-up of 1 year no relapse of MALT lymphoma occurred. Low-grade primary gastric MALT lymphoma can completely regress after eradication of H pylori infection. However, longer follow-up is needed to clarify whether the remission is lasting.