LIPOPROTEIN-LP(A) AND THE RISK FOR MYOCARDIAL-INFARCTION
LIPOPROTEIN-LP(A) AND THE RISK FOR MYOCARDIAL-INFARCTION
复制标题
DOI：
10.1016/0021-9150(81)90103-9
复制
发表时间：
1981-01-01
期刊：
影响因子：
5.3
通讯作者：
QUNICI, GB
中科院分区：
文献类型：
--
作者：
KOSTNER, GM;AVOGARO, P;QUNICI, GB
本文测定了76例40-60岁男性心肌梗塞（MI）患者和107例同年龄、同性别对照者的血清脂蛋白Lp（a）浓度。通过Laurell技术进行定量。在1-60 mg/dl范围内灵敏，日间变异系数<4%。Lp（a）浓度在整个人群中有相当大的变化，具有高阶频率分布。传统的统计学方法不能用于评价Lp（a）可能的MI风险。除Lp（a）外，还检测了其他几种动脉粥样硬化的危险因素和抗危险因素。将整个人群分为正常脂血症（NL）和IIa、IIb和IV型表型。受试者分为2或3种Lp（a）类型，选择几个不同的Lp（a）浓度临界点。与MI患者相比，NL对照组的总胆固醇和低密度脂蛋白（LDL）-胆固醇显著降低，但高密度脂蛋白（HDL）-胆固醇值较高。高密度脂蛋白胆固醇浓度显着不同IIa型对照和MI患者。11%的NL对照组和25%的NL-MI患者显示Lp（a）值> 50 mg/dl。Lp（a）浓度高于此值表示MI的相对风险为2.3倍。在IIa型和IIb型人群中获得了类似的结果，但在IV型糖尿病患者中没有。以30 mg/dl作为临界点，Lp（a）代表NL人群中MI的相对风险为1.75。高脂血症患者（对照组+ MI）的Lp（a）值通常高于NL。所有数据的统计学评估未能揭示Lp（a）水平与动脉粥样硬化的其他风险或抗风险因素之间的任何相关性。Lp（a）显然代表MI的独立的附加风险因素，其可能的阈值为apxx。NL中30 mg/dl。
The serum lipoprotein Lp(a) concentration was measured in 76 male postmyocardial infarction (MI) patients aged 40-60 yr, and in 107 control subjects of the same age and sex. Quantitation was performed by the Laurell technique. It was sensitive in the range 1-60 mg/dl with a day to day coefficient of variation < 4%. A considerable variation of Lp(a) concentration was noticed in the whole population with a frequency distribution of higher order. Conventional statistical methods could not be applied to evaluate a possible MI risk of Lp(a). In addition to Lp(a), several other risk and anti-risk factors for atherosclerosis were assayed. The whole population was divided into normolipemics (NL) and Type IIa, IIb and IV phenotypes. The subjects were grouped into 2 or 3 Lp(a)-types, selecting several different cutoff points for Lp(a) concentrations. NL-controls had significantly lower total cholesterol and low density lipoprotein (LDL)-cholesterol but higher high density lipoprotein (HDL)-cholesterol values compared to the MI-patients. The HDL-cholesterol concentration was significantly different between Type IIa controls and MI-patients. Eleven percent of the NL-controls, but 25% of the NL-MI-patients exhibited Lp(a) values > 50 mg/dl. Lp(a) concentration above this value represents a 2.3-fold relative risk for MI. Similar findings were obtained in the Type IIa and IIb populations, but not in Type IV hyperlipemics. Taking 30 mg/dl as the cutoff point, Lp(a) represents a relative risk of 1.75 for MI in the NL population. Hyperlipemics in general (controls + MI) exhibited higher Lp(a) values compared to NL. Statistical evaluation of all the data failed to reveal any correlation between Lp(a) levels and other risk or anti-risk factors for atherosclerosis. Lp(a) evidently represents an independent additional risk factor for MI with a possible threshold value of .apprx. 30 mg/dl in NL.