Three-component solvent-free synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen
Three-component solvent-free synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen
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DOI：
10.1039/c0gc00373e
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发表时间：
2010-01-01
期刊：
影响因子：
9.8
通讯作者：
Lin, Jun
中科院分区：
文献类型：
--
作者：
Yan, Shengjiao;Chen, Yulan;Lin, Jun
从简单易得的原料出发，采用一锅法、三组分法合成了高取代度的双环吡啶类化合物。在无溶剂和无催化剂的条件下，杂环烯酮缩胺（HKA）、三乙氧基甲烷和活性亚甲基化合物通过环化缩合反应以优异的产率得到双环吡啶。
An efficient one-pot, three-component synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen, starting from simple and readily available materials, is described. Cyclocondensation of heterocyclic ketene aminals (HKAs), triethoxymethane, and active methylene compounds by refluxing under solvent-free and catalyst-free conditions, provided bicyclic pyridines in excellent yields.