Baseline and early natural history report. The Central Vein Occlusion Study.
Baseline and early natural history report. The Central Vein Occlusion Study.
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发表时间：
1993
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通讯作者：
J. Clarkson;E. Chuang;D. Gass;M. Pedroso;T. Cubillas;E. S. Duria;D. Hess;I. Rams;A. Gutierrez;P. Kiès;N. Muniz;M. Pall;C. Pappas;D. Finkelstein;A. Patz;D. Rytel;J. Belt;D. Cain;A. Hillis
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作者：
J. Clarkson;E. Chuang;D. Gass;M. Pedroso;T. Cubillas;E. S. Duria;D. Hess;I. Rams;A. Gutierrez;P. Kiès;N. Muniz;M. Pall;C. Pappas;D. Finkelstein;A. Patz;D. Rytel;J. Belt;D. Cain;A. Hillis
目的评价缺血性中央静脉阻塞的全视网膜光凝术和中央静脉阻塞导致视力下降的黄斑水肿的黄斑网格图案光凝术，并进一步确定中央静脉阻塞的自然病史。设计：由美国国家眼科研究所（Bethesda，MD）支持的多中心随机对照临床试验。725例患者的728只眼睛被分为四个研究组中的一个或多个：灌注组、非灌注组、不确定灌注组和黄斑水肿组。结果：研究患者的随访仍在进行中，随机分组（非灌注组和黄斑水肿组）没有结果。不确定组的46只可评估眼中，有38只（83%）最终显示至少10个椎间盘区域无灌注（28只眼睛）或在确定视网膜状态之前出现虹膜和/或房角新生血管（10只眼睛）。灌注组的547只眼睛中有522只获得了4个月的随访信息。这522只眼睛中有30只在4个月随访访视时或之前显示虹膜和/或房角新生血管。另外51只眼睛在4个月访视时出现了至少10个椎间盘非灌注区域的证据。结论：这些发现证实了频繁随访检查的重要性，包括虹膜的未扩张裂隙灯检查和前房角镜检查在治疗所有近期发生中心静脉闭塞的患者中的重要性。
OBJECTIVES To evaluate panretinal photocoagulation for ischemic central vein occlusion and macular grid-pattern photocoagulation for macular edema with reduced visual acuity due to central vein occlusion and to further define the natural history of central vein occlusion. DESIGN A multicenter randomized controlled clinical trial supported by the National Eye Institute, Bethesda, Md. PATIENTS A total of 728 eyes from 725 patients were entered into one or more of four study groups: perfused, nonperfused, indeterminate perfusion, and macular edema. RESULTS Follow-up of study patients is still in progress and no results are available for the randomized groups (nonperfused and macular edema). Thirty-eight (83%) of 46 evaluable eyes in the indeterminate group eventually demonstrated at least 10 disc areas of nonperfusion (28 eyes) or developed iris and/or angle neovascularization before retinal status could be determined (10 eyes). Four-month follow-up information is available for 522 of the 547 eyes in the perfused group. Thirty of these 522 eyes demonstrated iris and/or angle neovascularization at or before the 4-month follow-up visit. An additional 51 eyes had developed evidence of at least 10 disc areas of nonperfusion by the time of the 4-month visit. CONCLUSIONS These findings confirm the importance of frequent follow-up examinations, including undilated slit-lamp examination of the iris, and gonioscopy in the management of all patients with recent onset of central vein occlusion.