Calcium ion and muscle contraction.
Calcium ion and muscle contraction.
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DOI：
10.1016/0079-6107(68)90023-0
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发表时间：
1968-01-01
影响因子：
3.8
通讯作者：
Endo, M
中科院分区：
文献类型：
--
作者：
Ebashi, S;Endo, M
钙离子现在通常被认为是生理条件下收缩系统的最终激活剂。然而，直到最近，这一想法才被广泛接受。钙离子的生理作用在肌肉收缩的生物化学研究中几乎被完全忽视。虽然某些生理学家已经证明了钙离子在这一时期的收缩诱导作用，但他们的发现并没有得到立即的关注。具有讽刺意味的是，钙离子在收缩中的重要作用的认识主要来自于对松弛机制的研究，关于”松弛因子”，以前已经发表了各种评论（例如哈塞尔巴赫，1964 a; Ebashi，1965 b; Smith，1966; A. Weber，1966）。因此，我们将把目前关于放宽因素的审查限于简要描述历史方面的情况，并介绍仍在审议中的具体问题。重点将放在目前的观点，而关于肌肉的生理事件的基础上的“放松因子”，以及钙离子，也对钙离子的作用作为一个调节剂的收缩系统在生理条件下的分子机制。不
The calcium ion is now generally considered to be the final activator of the contractile system under physiological conditions. However, it is only recently that this idea has become widely accepted. The physiological role of Ca ion had been almost completely overlooked in the biochemical approach to the study of muscular contraction. Although certain physiologists had demonstrated the contraction inducing effect of Ca ion during this period, their finding did not receive immediate attention. It is rather ironic that recognition of the essential role of Ca ion in contraction has resulted mainly from the investigation into the mechanism of relaxation.Various reviews have previously been published with regard to the" relaxing factor"(eg Hasselbach, 1964a; Ebashi, 1965b; Smith, 1966; A. Weber, 1966). Therefore, we shall confine the present review concerning the relaxing factor to a brief description of historical aspects and to a presentation of the particular problems which are still under consideration. Emphasis will be placed rather on current views concerning physiological events of muscle based on the" relaxing factor" as well as Ca ion, and also on the molecular mechanism of the action of Ca ion as a regulating agent of the contractile system under physiological conditions. t