Serotonin Prevents Differentiation of Brown Adipocytes by Interfering with Their Clock

Serotonin Prevents Differentiation of Brown Adipocytes by Interfering with Their Clock
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血清素通过干扰棕色脂肪细胞的时钟来防止其分化

DOI:
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发表时间:
2019
期刊:
影响因子:
6.9
通讯作者:
O. Froy
O. Froy
中科院分区:
医学2区
文献类型:
--
作者:
Sigal Rozenblit;N. Chapnik;O. Froy

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血清素被证明会干扰棕色脂肪细胞的分化。此外,时钟成分通过直接转录控制转化生长因子β途径的关键成分来抑制棕色脂肪生成。本研究的目的是调查血清素是否通过影响时钟功能来消除棕色脂肪的生成。
Serotonin was shown to interfere with the differentiation of brown adipocytes. In addition, clock components inhibit brown adipogenesis through direct transcriptional control of key components of the transforming growth factor β pathway. The aim of this study was to investigate whether serotonin abrogates brown adipogenesis by affecting clock functionality.
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