Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain
Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain
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DOI：
10.1242/dev.041699
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发表时间：
2010-01-01
期刊：
影响因子：
4.6
通讯作者：
Lee, Tzumin
中科院分区：
文献类型：
--
作者：
Lin, Suewei;Lai, Sen-Lin;Lee, Tzumin
Numb可以拮抗Notch信号，使姐妹细胞的命运多样化。我们在这里报道，成对的姐妹细胞在所有三种果蝇神经元谱系中获得不同的命运，这些神经元谱系构成不同类型的触角叶投射神经元(PNS)。在前背(Ad)和腹侧(V)PN谱系中，每对有丝分裂后神经元中只有一个能存活到成年期。值得注意的是，Notch信号指定了VPN谱系中的PN命运，但促进了adPN谱系中缺失兄弟姐妹的程序性细胞死亡。此外，Notch/Numb介导的双亲命运是IAL谱系中共同前体产生PNS和局部中间神经元的基础。此外，Numb需要在外侧，而不是adPN或VPN谱系中，以防止异位神经母细胞的出现，并确保神经前体细胞的适当自我更新。这些Notch/Numb信号的谱系特异性输出表明，二元命运决定的通用机制可以用于管理不同的神经兄弟姐妹分化。
Numb can antagonize Notch signaling to diversify the fates of sister cells. We report here that paired sister cells acquire different fates in all three Drosophila neuronal lineages that make diverse types of antennal lobe projection neurons (PNs). Only one in each pair of postmitotic neurons survives into the adult stage in both anterodorsal (ad) and ventral (v) PN lineages. Notably, Notch signaling specifies the PN fate in the vPN lineage but promotes programmed cell death in the missing siblings in the adPN lineage. In addition, Notch/Numb-mediated binary sibling fates underlie the production of PNs and local interneurons from common precursors in the IAL lineage. Furthermore, Numb is needed in the lateral but not adPN or vPN lineages to prevent the appearance of ectopic neuroblasts and to ensure proper self-renewal of neural progenitors. These lineage-specific outputs of Notch/Numb signaling show that a universal mechanism of binary fate decision can be utilized to govern diverse neural sibling differentiations.