Bioabsorbable stents: only bad news?
Bioabsorbable stents: only bad news?
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DOI：
10.1093/eurheartj/suz009
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发表时间：
2019-03-01
影响因子：
1.6
通讯作者：
Capodanno, Davide
中科院分区：
文献类型：
--
作者：
Buccheri, Sergio;Capodanno, Davide
冠状动脉支架植入术已成为经皮冠状动脉介入治疗（PCI）手术的组成部分，为治疗的血管提供结构支撑，并防止简单球囊扩张后发生的急性回缩、再狭窄和晚期负性重塑。支架生物可吸收装置（BRS）的引入，能够为血管提供临时的结构支撑，同时洗脱抗增殖药物，并以可预测的时间方式被重吸收，代表了经皮介入的最新技术创新。1在PCI期间使用BRS的合理性和潜在优势有很多，大多数是不言而喻的。特别值得关注的是，一旦重吸收完成，可以重建血管的正常形态和生理学（运动性、血管几何形状和剪切应力），从而限制长期抗血小板治疗，这是避免支架血栓形成所必需的。2从技术-手术的角度来看，BRS的重吸收在复杂的解剖情况下具有优势，例如分叉支架植入术或口部区域的PCI，其中可以减少BRS的悬垂。
Coronary stenting has become an integral part of percutaneous coronary intervention (PCI) procedures, providing structural support to the treated vessel and preventing acute recoil, restenosis, and late negative remodelling occurring after simple balloon dilation. The introduction of scaffold bioabsorbable device (BRS), able to provide temporary structural support to a vessel, while eluting an antiproliferative drug, and be reabsorbed in a time-predictable fashion, represent the latest technological innovation in percutaneous intervention. 1 The rational and the potential advantages for the use of BRS during PCI are numerous and mostly self-evident.Of particular interest is the possibility of re-establishing normal morphology and physiology (motility, vessel geometry, and shear stress) of the vessel once the reabsorption is complete, allowing to limit the antiplatelet treatment in the long term, which is necessary to avert stent thrombosis. 2 Form a technical-procedural stand-point, the reabsorption of the BRS could offer advantages in complex anatomical situations such as bifurcation stenting, or PCI in ostial regions in which could reduce the overhanging of the