Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake.
Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake.
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DOI：
10.1253/circj.cj-12-1238
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发表时间：
2012-11
期刊：
影响因子：
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通讯作者：
T. Nihei;J. Takahashi;Y. Kikuchi;Yusuke Takagi;K. Hao;R. Tsuburaya;T. Shiroto;Yoshitaka Ito;Y. Matsumoto;M. Nakayama;K. Ito;S. Yasuda;H. Shimokawa
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文献类型：
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作者：
T. Nihei;J. Takahashi;Y. Kikuchi;Yusuke Takagi;K. Hao;R. Tsuburaya;T. Shiroto;Yoshitaka Ito;Y. Matsumoto;M. Nakayama;K. Ito;S. Yasuda;H. Shimokawa
背景目前尚不清楚血管痉挛性心绞痛（VSA）的疾病活动是否在灾难期间发生改变。方法和结果 在东日本大地震前后，我们通过创伤后应激障碍（PTSD）问卷调查了 11 名 VSA 患者循环中性粒细胞中的 Rho 激酶活性及其精神压力。 Rho激酶活性在地震后6个月显着增加，并在12个月时恢复到基线水平。重要的是，Rho 激酶活性的百分比变化与 PTSD 评分显着相关。结论 这些结果表明 VSA 患者的 Rho 激酶活性短暂增强与灾难相关的精神压力有关。
BACKGROUND It remains unclear whether disease activity of vasospastic angina (VSA) is altered during a disaster. METHODS AND RESULTS Before and after the Great East Japan Earthquake, we examined Rho-kinase activity in circulating neutrophils of 11 VSA patients and their mental stress with the post-traumatic stress disorder (PTSD) questionnaire. Rho-kinase activity was significantly increased at 6 months after the Earthquake, and was returned to baseline level at 12 months. Importantly, percent change in Rho-kinase activity was significantly correlated with the PTSD score. CONCLUSIONS These results indicate that the Rho-kinase activity of VSA patients was transiently enhanced associated with disaster-related mental stress.