EFFECT OF CHRONIC ATRIAL-FIBRILLATION ON REGIONAL CEREBRAL BLOOD-FLOW
EFFECT OF CHRONIC ATRIAL-FIBRILLATION ON REGIONAL CEREBRAL BLOOD-FLOW
复制标题
DOI：
10.1161/01.str.11.1.35
复制
发表时间：
1980-01-01
期刊：
影响因子：
8.3
通讯作者：
LEVY, P
中科院分区：
文献类型：
--
作者：
LAVY, S;STERN, S;LEVY, P
通过吸入133氚同时测量双侧脑局部血流量（rCBF）的非侵入性技术的发展为评价各种心脏条件下的脑循环提供了一种安全的方法。通过吸入133 Xe测量了31名无心力衰竭症状且无神经系统疾病的慢性房颤患者的局部脑血流量。年龄35-80岁，平均60.3岁。31例患者中有27例的rCBF低于年龄匹配的正常对照组。不同年龄组的脑血流量从17.5%减少到5.5%，平均rCBF减少最多（17.5%）的是较年轻的年龄组（35-50岁）。在51-65岁的患者组中，减少了13.4%，而在> 65岁的患者中，仅减少了5.5%。在这些患者中观察到的rCBF减少显然没有达到产生脑表现所需的水平。任何叠加的节律或速率病理和/或脑动脉硬化都可能进一步损害脑循环。虽然脑栓塞是心律失常脑表现的常见原因，但应考虑脑血管疾病患者因心率或节律紊乱而导致的脑灌注慢性减少。早期识别和治疗慢性心律失常伴脑灌注减少可能会预防后期神经系统并发症。
The development of a non-invasive technique for simultaneous bihemispheric measurement of regional cerebral blood flow (rCBF) by inhalation of 133Xe made available a safe method for evaluation of cerebral circulation under various cardiac conditions. Regional cerebral blood flow was measured by 133Xe inhalation in 31 patients with chronic atrial fibrillation without symptoms of heart failure and free from neurological diseases. Their age ranged from 35-80 (mean 60.3 yr). In 27 of the 31 patients rCBF was lower than for age-matched normal control subjects. A reduction in cerebral blood flow from 17.5 to 5.5% in various age groups was found. The highest reduction in mean rCBF (17.5%) was found in the younger age group (35-50 yr). In the group of patients between 51-65 yr, the reduction was 13.4% and in the patients > 65, only 5.5%. The reduction of rCBF observed in these patients apparently did not reach the level required to produce cerebral manifestations. Any superimposed rhythm or rate pathology and/or cerebral arteriosclerosis may further compromise the cerebral circulation. Although cerebral emboli are a frequent cause of cerebral manifestations in cardiac arrhythmia a chronic reduction in cerebral perfusion consequent to rate or rhythm disturbances in patients with cerebral vascular diseases should be considered. Early recognition and therapy of chronic arrhythmia with reduced cerebral perfusion may prevent neurological complications at a later stage.