Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.
Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.
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DOI：
10.1016/j.chom.2016.12.006
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发表时间：
2017-01-11
影响因子：
30.3
通讯作者：
Gordon JI
中科院分区：
文献类型：
--
作者：
Griffin NW;Ahern PP;Cheng J;Heath AC;Ilkayeva O;Newgard CB;Fontana L;Gordon JI
无论之前的饮食习惯（DP）如何，确保肠道微生物群对规定的饮食干预措施一致反应对于有效的营养治疗至关重要。为了解决这个问题，我们在有足够营养的慢性热量限制（CRON）或没有饮食限制（AMER）的个体中鉴定了与 DP 相关的肠道细菌分类群。当移植到限生小鼠体内时，AMER 和 CRON 微生物群对 CRON 和 AMER 饮食产生了可预测的反应，但反应强度各不相同。个体的微生物群通过微生物交换与其他个体的群落（“元群落”）相连。将 AMER 定植小鼠与两组不同的 CRON 定植小鼠连续饲养，模拟了元群落效应，从而增强了对 CRON 饮食干预的反应，并改变了 AMER 动物的几种代谢特征。这种反应是由 CRON DP 相关类群的涌入驱动的。某些 DP 可能会损害对饮食干预的反应，因此需要引入其他个体中存在的饮食反应性细菌谱系，并使用所述策略进行鉴定。
Ensuring that gut microbiota respond consistently to prescribed dietary interventions, irrespective of prior dietary practices (DPs), is critical for effective nutritional therapy. To address this, we identified DP-associated gut bacterial taxa in individuals either practicing chronic calorie restriction with adequate nutrition (CRON) or without dietary restrictions (AMER). When transplanted into gnotobiotic mice, AMER and CRON microbiota responded predictably to CRON and AMER diets but with variable response strengths. An individual’s microbiota is connected to other individuals’ communities (‘metacommunity’) by microbial exchange. Sequentially cohousing AMER-colonized mice with two different groups of CRON-colonized mice simulated metacommunity effects, resulting in enhanced responses to a CRON diet intervention and changes in several metabolic features in AMER animals. This response was driven by an influx of CRON DP-associated taxa. Certain DPs may impair responses to dietary interventions, necessitating the introduction of diet-responsive bacterial lineages present in other individuals and identified using the strategies described.