Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer.
Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer.
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精氨酸代谢及其治疗结直肠癌的潜力
DOI：
10.3389/fcell.2021.658861
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发表时间：
2021
影响因子：
5.5
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Du T;Han J
结直肠癌是全球癌症死亡的主要原因。目前的治疗方案仍然严重依赖于早期发现和手术。结直肠癌发生的分子机制在临床上具有重要意义，并决定预后和治疗反应。结直肠癌中精氨酸代谢通路异常活跃，参与该通路的一些分子是化学预防和结直肠癌靶向治疗的潜在靶点。内皮型一氧化氮合酶（eNOS）、精氨酸琥珀酸合成酶（arginino琥珀酸合成酶）和鸟氨酸脱羧酶（ODC）是精氨酸代谢的主要酶。限制富含精氨酸的肉类消费和抑制ODC活性在很大程度上减少了多胺合成和结直肠癌的发病率。精氨酸转运蛋白CAT-1和溶质载体家族6 （SLC6A14）的人类成员14在结直肠癌细胞中过表达，并影响细胞内精氨酸水平。溶质载体家族38的人类成员9 （SLC38A9）是溶酶体精氨酸感知机制的一个组成部分。药物抑制单个酶或精氨酸转运体难以满足异常精氨酸代谢网络恢复的需要。除了在结直肠癌早期筛查中的应用外，同时调控精氨酸代谢多个靶点的基于microrna的治疗策略在结直肠癌的治疗中具有广阔的应用前景。
Colorectal cancer is the leading cause of death from cancer globally. The current treatment protocol still heavily relies on early detection and surgery. The molecular mechanisms underlying development of colorectal cancer are clinically important and determine the prognosis and treatment response. The arginine metabolism pathway is hyperactive in colorectal cancer and several molecules involved in the pathway are potential targets for chemoprevention and targeted colorectal cancer therapy. Endothelial nitric oxide synthase (eNOS), argininosuccinate synthetase and ornithine decarboxylase (ODC) are the main enzymes for arginine metabolism. Limiting arginine-rich meat consumption and inhibiting ODC activity largely reduces polyamine synthesis and the incidence of colorectal cancer. Arginine transporter CAT-1 and Human member 14 of the solute carrier family 6 (SLC6A14) are overexpressed in colorectal cancer cells and contributes to intracellular arginine levels. Human member 9 of the solute carrier family 38 (SLC38A9) serves as a component of the lysosomal arginine-sensing machinery. Pharmaceutical inhibition of single enzyme or arginine transporter is hard to meet requirement of restoring of abnormal arginine metabolic network. Apart from application in early screening for colorectal cancer, microRNA-based therapeutic strategy that simultaneously manipulating multiple targets involved in arginine metabolism brings promising future in the treatment of colorectal cancer.
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艾姆斯侏儒小鼠肝脏中的 MicroRNA 调节可能有助于延缓衰老。
影响因子：
7.8
作者：
Bates DJ;Li N;Liang R;Sarojini H;An J;Masternak MM;Bartke A;Wang E
通讯作者：
Wang E
DOI：
10.1158/1078-0432.ccr-08-3213
发表时间：
2009-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
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通讯作者：
Hogarty MD
DOI：
10.1073/pnas.1404171111
发表时间：
2014-09-30
影响因子：
11.1
作者：
Changou, Chun A.;Chen, Yun-Ru;Kung, Hsing-Jien
通讯作者：
Kung, Hsing-Jien
影响因子：
168.9
作者：
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通讯作者：
Starling, Naureen
影响因子：
3.4
作者：
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通讯作者：
Shochina, M