The Tumorigenic Role of Circular RNA-MicroRNA Axis in Cancer.
The Tumorigenic Role of Circular RNA-MicroRNA Axis in Cancer.
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DOI：
10.3390/ijms24033050
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发表时间：
2023-02-03
影响因子：
5.6
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中科院分区：
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环状rna （circRNAs）是一类内源性rna，在转录和转录后水平上控制基因表达。最近的研究越来越多地表明，环状rna通过与其他非编码rna如microRNAs （miRNAs）相互作用，作为新的诊断生物标志物和许多癌症类型的有希望的治疗靶点。mirna通过调控其靶基因的表达而被认为是癌症的关键危险因素和调控元件。一些mirna来源于转座元件（mdte），可以将它们的位置转移到基因组的另一个区域。mirna和环状rna之间的遗传相互作用可以形成复杂的调控网络，在肿瘤发生和癌症进展中发挥关键作用。本文综述了不同类型肿瘤中环状rna、mirna及其靶基因之间相关轴的生物学调控，并提出了mdte与致癌或肿瘤抑制环状rna相互作用在肿瘤进展中的生物学重要性。
Circular RNAs (circRNAs) are a class of endogenous RNAs that control gene expression at the transcriptional and post-transcriptional levels. Recent studies have increasingly demonstrated that circRNAs act as novel diagnostic biomarkers and promising therapeutic targets for numerous cancer types by interacting with other non-coding RNAs such as microRNAs (miRNAs). The miRNAs are presented as crucial risk factors and regulatory elements in cancer by regulating the expression of their target genes. Some miRNAs are derived from transposable elements (MDTEs) that can transfer their location to another region of the genome. Genetic interactions between miRNAs and circular RNAs can form complex regulatory networks with various carcinogenic processes that play critical roles in tumorigenesis and cancer progression. This review focuses on the biological regulation of the correlative axis among circular RNAs, miRNAs, and their target genes in various cancer types and suggests the biological importance of MDTEs interacting with oncogenic or tumor-suppressive circRNAs in tumor progression.