δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF
δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF
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DOI：
10.1016/j.febslet.2012.11.024
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发表时间：
2013-01-16
期刊：
影响因子：
3.5
通讯作者：
Kim, Kwonseop
中科院分区：
文献类型：
--
作者：
He, Yongfeng;Kim, Hangun;Kim, Kwonseop
这项研究表明，在CAM测定中，过表达δ-连环蛋白的CWR 22 Rv-1细胞显示出比其匹配的对照细胞更大的肿瘤形成和更高的血管生成潜力。此外，CWR 22 Rv-1细胞中δ-连环蛋白过表达导致缺氧诱导因子1-α（HIF-1 α）和血管内皮生长因子（VEGF）表达增加。此外，发现δ-连环蛋白过表达增强缺氧条件下β-连环蛋白和HIF-1 α的核分布，这通过敲低δ-连环蛋白而减弱。我们目前的研究增加了关于δ-连环蛋白对前列腺癌进展的贡献的新证据。(C)2012年欧洲生物化学学会联合会。由Elsevier B出版。V.保留所有权利。
This study revealed that CWR22Rv-1 cells overexpressing delta-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay. In addition, delta-catenin overexpression in CWR22Rv-1 cells results in increased hypoxia-inducible factor 1-alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) expression. Furthermore, delta-catenin overexpression was found to enhance nuclear distribution of both beta-catenin and HIF-1 alpha in hypoxic condition, which is diminished by knockdown of delta-catenin. Our current study adds novel evidence regarding contribution of delta-catenin to the progression of prostate cancer. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.