The predictive value of the preoperative fibrinogen-albumin ratio on the postoperative prognosis of renal cell carcinoma
The predictive value of the preoperative fibrinogen-albumin ratio on the postoperative prognosis of renal cell carcinoma
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术前纤维蛋白原-白蛋白比值对肾细胞癌术后预后的预测价值
DOI：
10.21037/tau-19-873
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发表时间：
2020-06-01
影响因子：
2
通讯作者：
Zhang, Qian
中科院分区：
文献类型：
--
作者：
Liu, Jun;Gan, Ying;Zhang, Qian
背景资料：泌尿外科医生迫切需要一种简单、有效、准确的临床生物标志物，以尽早识别预后不良和复发风险高的肾细胞癌（RCC）患者。因此，我们研究了术前纤维蛋白原-白蛋白比值（FAR）在肾细胞癌患者中的预后价值。方法：回顾性分析北京大学第一医院2010 - 2012年收治的279例肾癌患者的临床资料。采用受试者工作特征（ROC）曲线分析获得FAR的最佳截止值，并将患者分为高FAR组和低FAR组。采用卡方检验分析术前FAR与临床病理特征的相关性。采用Log-rank检验和考克斯比例风险回归模型评价临床病理参数对总生存期（OS）的预测价值。结果：FAR的最佳截断值为0.116。FAR >0.116与高Fuhrman分级相关（P
Background: Urologists urgently need a simple, effective, accurate clinical biomarker to identify renal cell carcinoma (RCC) patients with poor prognosis and those with a high risk of recurrence as early as possible. Therefore, we investigated the prognostic value of the preoperative fibrinogen-albumin ratio (FAR) in patients with RCC. Methods: We retrospectively analyzed data from 279 cases of renal cancer admitted to the First Hospital of Peking University from 2010 to 2012. The best cutoff value of the FAR was obtained using receiver operating characteristic (ROC) curve analysis, and patients were divided into high- and low-FAR groups. The correlation between the preoperative FAR and clinicopathological features was analyzed by chi(2) test. Log-rank test and Cox proportional hazard regression model were used to evaluate the predictive value of clinicopathological parameters for overall survival (OS). Results: The best cutoff value for the FAR was 0.116. A FAR >0.116 was associated with higher Fuhrman grade (P