Gluten sensitivity: from gut to brain
Gluten sensitivity: from gut to brain
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DOI：
10.1016/s1474-4422(09)70290-x
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发表时间：
2010-03-01
期刊：
影响因子：
48
通讯作者：
Aeschlimann, Daniel
中科院分区：
文献类型：
--
作者：
Hadjivassiliou, Marios;Sanders, David S.;Aeschlimann, Daniel
谷蛋白敏感性是一种表现多样的全身自身免疫性疾病。这种疾病的特征是遗传易感个体对摄入谷蛋白的异常免疫反应。乳糜泻，或谷蛋白敏感性肠病，只是谷蛋白敏感性一系列可能表现的一个方面。虽然自1966年以来就有确诊乳糜泻患者的神经系统表现的报道，但直到30年后，在一些个体中，麸质敏感性才被证明仅表现为神经功能障碍。此外，没有肠病的肠外表现的概念直到最近才被接受。在这篇文章中，我们回顾了谷蛋白敏感性的神经学表现，并讨论了谷蛋白敏感性相关神经功能障碍的诊断和病理生理机制的最新进展。
Gluten sensitivity is a systemic autoimmune disease with diverse manifestations. This disorder is characterised by abnormal immunological responsiveness to ingested gluten in genetically susceptible individuals. Coeliac disease, or gluten-sensitive enteropathy, is only one aspect of a range of possible manifestations of gluten sensitivity. Although neurological manifestations in patients with established coeliac disease have been reported since 1966, it was not until 30 years later that, in some individuals, gluten sensitivity was shown to manifest solely with neurological dysfunction. Furthermore, the concept of extraintestinal presentations without enteropathy has only recently become accepted. In this Personal View, we review the range of neurological manifestations of gluten sensitivity and discuss recent advances in the diagnosis and understanding of the pathophysiological mechanisms underlying neurological dysfunction related to gluten sensitivity.