DETERMINANTS OF INCREASED DRUG SELF-ADMINISTRATION DUE TO FOOD-DEPRIVATION
DETERMINANTS OF INCREASED DRUG SELF-ADMINISTRATION DUE TO FOOD-DEPRIVATION
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DOI：
10.1007/bf00427092
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发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
MEISCH, RA
中科院分区：
文献类型：
--
作者：
CARROLL, ME;MEISCH, RA
Changes in oral etonitazene self-administration were compared in 4 groups of rats that were maintained at 100, 95, 85 or 75% of their pre-experimental free-feeding body weights. Etonitazene (5 .mu.g/ml) or water was available for 16 h according to a fixed-ratio (FR) 1 schedule. Each liquid delivery (0.1 ml) was contingent upon a lever-press response. During food deprivation etonitazene intake gradually increased to over 2-fold as body weights decreased over 25 sessions; etonitazene intake was inversely proportional to body weight. The 75% weight group showed stereotypy, self-mutilation and large variability in daily etonitazene intake. In another experiment a range of deprivation conditions was studied in a group of 6 rats with etonitazene (5 .mu.g/ml) or water available on an FR 8 schedule during 1 h sessions. When the rats were gradually food satiated, etonitazene-maintained behavior declined but remained higher than water-maintained behavior; when they were abruptly food satiated, etonitazene-maintained behavior decreased to low levels.
