Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain
Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain
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DOI：
10.1038/s41598-019-46240-6
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发表时间：
2019-07-09
影响因子：
4.6
通讯作者：
Sato, Chihiro
中科院分区：
文献类型：
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作者：
Abe, Chikara;Yi, Yang;Sato, Chihiro
压力是影响人类行为并导致若干精神障碍的重要环境因素。由于编码聚唾液酸合成酶的ST 8 SIA 2的遗传改变，聚唾液酸（polySia/PSA）结构的改变与某些精神障碍有关。然而，应力作为环境因素是否导致polySia结构的变化尚不清楚。在这里，我们研究了急性应激对polySia表达的影响，发现即使短期暴露于急性应激，嗅球和前额叶皮层中polySia的数量和质量也会减少。唾液酸酶，小胶质细胞和星形胶质细胞的抑制剂的使用表明，这些下降是由于唾液酸酶从嗅球和前额叶皮层中的小胶质细胞和星形胶质细胞的瞬时作用，分别。这些数据表明，唾液酸酶以脑区域特异性方式动态调节polySia表达。
Stress is an important environmental factor influencing human behaviour and causing several mental disorders. Alterations in the structure of polysialic acid (polySia/PSA) due to genetic alterations in ST8SIA2, which encodes a polySia-synthesizing enzyme, are related to certain mental disorders. However, whether stress as an environmental factor leads to changes in polySia structure is unknown. Here we studied the effects of acute stress on polySia expression and found reductions in both the quantity and quality of polySia in the olfactory bulb and prefrontal cortex, even with short-term exposure to acute stress. The use of inhibitors for sialidase, microglia and astrocytes revealed that these declines were due to a transient action of sialidase from microglia and astrocytes in the olfactory bulb and prefrontal cortex, respectively. These data suggest that sialidase dynamically regulates polySia expression in a brain region-specific manner.