Active Accumulation of Gold Nanorods in Tumor in Response to Near-Infrared Laser Irradiation
Active Accumulation of Gold Nanorods in Tumor in Response to Near-Infrared Laser Irradiation
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DOI：
10.1021/bc100284s
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发表时间：
2010-11-01
影响因子：
4.7
通讯作者：
Niidome, Takuro
中科院分区：
文献类型：
--
作者：
Shiotani, Atsushi;Akiyama, Yasuyuki;Niidome, Takuro
金纳米棒，棒状的金纳米颗粒，在近红外区域有很强的吸收能力，吸收的光能可以转化为热能，即所谓的光热效应。金纳米棒上涂有热响应聚合物，这些聚合物具有不同的相变温度，通过在 N-异丙基丙烯酰胺 (NIPAM) 中添加共聚单体 N,N-二甲基丙烯酰胺 (DMAA) 或丙烯酰胺 (AAm) 来控制相变温度。聚(NIPAM-DMAA)和聚(NIPAM-AAm)涂覆的金纳米棒的相变温度分别为38和41摄氏度，而聚NIPAM涂覆的金纳米棒在34摄氏度时显示出相变。由于聚合物的相变，使用近红外激光照射涂覆的金纳米棒导致其尺寸减小。 层。静脉注射后，聚（NIPAM-AAm）涂覆的金纳米棒在血流中稳定循环，无相变。注射后用近红外光照射肿瘤，导致金特异性地积聚在肿瘤中。这种新颖的积累技术结合了热响应聚合物和金纳米棒的光热效应，应该成为响应光照射的靶向递送的强大工具。
Gold nanorods, rod-shaped gold nanoparticles, have strong absorbance in the near-infrared region, and the absorbed light energy can be converted to heat, the so-called photothermal effect. The gold nanorods were coated with thermoresponsive polymers, which have different phase transition temperatures that were controlled by adding comonomers, N,N-dimethylacrylamide (DMAA) or acrylamide (AAm) to N-isopropylacrylamide (NIPAM). The phase transition temperatures of poly(NIPAM-DMAA) and poly(NIPAM-AAm)-coated gold nanorods were 38 and 41 degrees C, respectively, while polyNIPAM-coated gold nanorods showed phase transition at 34 degrees C. Irradiation of the coated gold nanorods using the near-infrared laser induced a decrease in their sizes due to a phase transition of the polymer layers. Poly(NIPAM-AAm)-coated gold nanorods stably circulated in the blood flow without a phase transition after intravenous injection. Irradiation of near-infrared light at a tumor after the injection resulted in the gold specifically accumulating in the tumor. This novel accumulation technique which combines a thermoresponsive polymer and the photothermal effect of the gold nanorods should be a powerful tool for targeted delivery in response to light irradiation.