Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere
Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere
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DOI：
10.1016/j.celrep.2019.10.067
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发表时间：
2019-11-19
期刊：
影响因子：
8.8
通讯作者：
Paul, Lynn K.
中科院分区：
文献类型：
--
作者：
Kliemann, Dorit;Adolphs, Ralph;Paul, Lynn K.
在健康人群中发现了一套可靠的功能性大脑网络，并被认为是我们认知、情感和行为的基础。在这里，我们通过量化六个接受手术切除一个半球的个体的内在功能连接来研究这些网络。半球切除术受试者和健康对照者在同一台扫描仪上使用相同的参数进行扫描，并与大型规范样本（n = 1,482）进行比较。令人惊讶的是，大脑半球切除术的受试者和对照组都显示出大脑区域之间强大而等效的半球内连接，这些区域通常分配给相同的功能网络。然而，在几乎所有半球切除术参与者和所有网络中，不同网络部分之间的连通性都显着增加。这些结果支持了认知基础上的一组共享功能网络的假设，并表明网络之间的相互作用可能是半球切除术中功能重组的特征。
A reliable set of functional brain networks is found in healthy people and thought to underlie our cognition, emotion, and behavior. Here, we investigated these networks by quantifying intrinsic functional connectivity in six individuals who had undergone surgical removal of one hemisphere. Hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a large normative sample (n = 1,482). Surprisingly, hemispherectomy subjects and controls all showed strong and equivalent intrahemispheric connectivity between brain regions typically assigned to the same functional network. Connectivity between parts of different networks, however, was markedly increased for almost all hemispherectomy participants and across all networks. These results support the hypothesis of a shared set of functional networks that underlie cognition and suggest that between-network interactions may characterize functional reorganization in hemispherectomy.