State-of-art neuroanatomical target analysis of high-definition and conventional tDCS montages used for migraine and pain control.
State-of-art neuroanatomical target analysis of high-definition and conventional tDCS montages used for migraine and pain control.
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DOI：
10.3389/fnana.2015.00089
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发表时间：
2015
影响因子：
2.9
通讯作者：
Bikson M
中科院分区：
文献类型：
--
作者：
DaSilva AF;Truong DQ;DosSantos MF;Toback RL;Datta A;Bikson M
尽管经颅直流电刺激（tDCS）研究有望调节与疼痛相关的皮层区域，但产生的电流通常会扩散到电极放置区域之外。使用前向模型分析，本研究比较了神经解剖位置和强度的预测电流峰值，在皮质和皮质下水平，诱导传统和高清晰度tDCS（HD-tDCS）蒙太奇开发的偏头痛和其他慢性疼痛疾病。根据10-20或10-10脑电图（EEG）标志定位电极：眶上运动皮质（M1-SO，阳极和阴极分别位于C3和Fp 2上），背外侧前额叶皮层（PFC）双侧（DLPFC，阳极在F3上，阴极在F4上），顶枕皮质（Cz上的阳极和Oz上的阴极）、HD-tDCS 4 × 1（C3上的一个阳极和Cz、F3、T7和P3上的四个阴极）和HD-tDCS 2 × 2（C3/C5上的两个阳极和FC 3/FC 5上的两个阴极）。M1-SO在PFC中产生大电流，在扣带回、丘脑、脑干等脑深部结构也出现电流峰值。使用Cz-Oz和DLPFC tDCS时，相同的结构接受了大量电流。然而，有差异的电流流向外皮层区域。视觉皮层，扣带回和丘脑接受了大部分的电流与Cz-Oz，而前部的上级和额中回显示了大量的电流与DLPFC蒙太奇。HD-tDCS导联增强了聚焦性，在皮质下区域产生可忽略水平的电流峰值。这项研究提供了新的信息，神经解剖分布和强度的电流使用几个tDCS蒙太奇适用于偏头痛和疼痛控制。这些信息可以帮助临床医生和研究人员决定最合适的tDCS蒙太奇来治疗每种疼痛疾病。
Although transcranial direct current stimulation (tDCS) studies promise to modulate cortical regions associated with pain, the electric current produced usually spreads beyond the area of the electrodes’ placement. Using a forward-model analysis, this study compared the neuroanatomic location and strength of the predicted electric current peaks, at cortical and subcortical levels, induced by conventional and High-Definition-tDCS (HD-tDCS) montages developed for migraine and other chronic pain disorders. The electrodes were positioned in accordance with the 10–20 or 10–10 electroencephalogram (EEG) landmarks: motor cortex-supraorbital (M1-SO, anode and cathode over C3 and Fp2, respectively), dorsolateral prefrontal cortex (PFC) bilateral (DLPFC, anode over F3, cathode over F4), vertex-occipital cortex (anode over Cz and cathode over Oz), HD-tDCS 4 × 1 (one anode on C3, and four cathodes over Cz, F3, T7, and P3) and HD-tDCS 2 × 2 (two anodes over C3/C5 and two cathodes over FC3/FC5). M1-SO produced a large current flow in the PFC. Peaks of current flow also occurred in deeper brain structures, such as the cingulate cortex, insula, thalamus and brainstem. The same structures received significant amount of current with Cz-Oz and DLPFC tDCS. However, there were differences in the current flow to outer cortical regions. The visual cortex, cingulate and thalamus received the majority of the current flow with the Cz-Oz, while the anterior parts of the superior and middle frontal gyri displayed an intense amount of current with DLPFC montage. HD-tDCS montages enhanced the focality, producing peaks of current in subcortical areas at negligible levels. This study provides novel information regarding the neuroanatomical distribution and strength of the electric current using several tDCS montages applied for migraine and pain control. Such information may help clinicians and researchers in deciding the most appropriate tDCS montage to treat each pain disorder.