Cleavage of the N-linked oligosaccharide from the surfaces of Chlamydia species affects infectivity in the mouse model of lung infection.
Cleavage of the N-linked oligosaccharide from the surfaces of Chlamydia species affects infectivity in the mouse model of lung infection.
复制标题
N-连接寡糖从衣原体表面的裂解会影响小鼠肺部感染模型的感染性。
DOI：
10.1128/iai.74.5.3027-3029.2006
复制
发表时间：
2006
影响因子：
3.1
通讯作者：
Kuo,Cho-chou
中科院分区：
文献类型：
--
作者：
Campbell,LeeAnn;Lee,Amy;Kuo,Cho-chou
以前的研究确定，衣壳聚糖含有一种高甘露糖低聚糖，它与生物体的附着和感染性有关，在体外，去除多糖会降低感染性。本研究表明，用N-葡聚糖酶处理该生物可降低或消除体内的感染性。
Previous studies determined that theChlamydiaglycan contains a high-mannose oligosaccharide, which is involved in attachment and infectivity of the organism, and that removal of the glycan decreases infectivity in vitro. The present study demonstrates that treatment of the organism withN-glycanase decreases or ablates infectivity in vivo.