Histiocytosis and virus: Merkel cell polyomavirus
Histiocytosis and virus: Merkel cell polyomavirus
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组织细胞增多症和病毒：默克尔细胞多瘤病毒
DOI：
10.11406/rinketsu.63.383
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
大畑 雅典
中科院分区：
文献类型：
--
作者：
村上 一郎;橋田 裕美子;樋口 智紀;大畑 雅典
组织细胞增多症是根据增殖的组织细胞样细胞分类的。朗格汉斯细胞组织细胞增生症（LCH）有几种亚型，具有不同的结局，从自发性到致命性消退，这些亚型已作为不同的疾病进行管理。然而，这些不同的疾病名称被统一为一种名为组织细胞增多症X的疾病，因为它们在病理学上是相同的。目前，LCH已被用作统一名称，因为增殖细胞具有朗格汉斯细胞的特征。从那时起，克隆性和BRAF突变已被报道，其肿瘤特征已变得清晰;然而，仅用肿瘤特征很难解释其各种亚型。炎症因子和LCH亚型之间的各种关系/相关性也是已知的。我们已经指出，默克尔细胞多瘤病毒可能参与LCH的发展，LCH是一种具有肿瘤性和反应性特征的疾病，即”一种具有肿瘤性特征的异常朗格汉斯样细胞对某些触发物过度反应的疾病。"
Histiocytosis is classified based on proliferating histiocyte-like cells. Langerhans cell histiocytosis (LCH) has several subtypes with various outcomes, from spontaneous to fatal regression, and these subtypes had been managed as different diseases. However, these different names of disease were unified to one disease named histiocytosis X since they are pathologically identical. Presently, LCH has been used as a unified name because proliferating cells have the characteristics of Langerhans cells. Since then, clonality and BRAF mutations have been reported, and their neoplastic characteristics has become clear; however, explaining its various subtypes is difficult with only the neoplastic character. Various relationships/correlations are also known between inflammatory factors and LCH subtypes. We have pointed out that the Merkel cell polyomavirus may be involved in LCH development and LCH is a disease with both neoplastic and reactive characters, that is," a disease in which abnormal Langerhans-like cells with neoplastic character overreact to some triggers."