Medial temporal lobe volume of nondemented elderly individuals with poor cognitive functions
Medial temporal lobe volume of nondemented elderly individuals with poor cognitive functions
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DOI：
10.1016/j.neurobiolaging.2005.07.020
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发表时间：
2006-09-01
影响因子：
4.2
通讯作者：
Hong, Seung Bong
中科院分区：
文献类型：
--
作者：
Chey, Jeanyung;Na, Dong Gyu;Hong, Seung Bong
在痴呆症评估中，经常难以解释受教育程度低的老年人的认知表现不佳。缺乏教育以及痴呆症通常与认知测试表现不佳有关。为了阐明低受教育程度低的老年人认知表现的潜在结构变化，这项研究检查了低认知能力（LCP）和脑部量，尤其是遭受阿尔茨海默氏病的地区，在纯净的韩国人中。 LCP（n = 14）的个体与具有正常认知表现的个体（n = 14）相匹配。在海马，内嗅皮层，杏仁核，颞叶，额叶，额叶，大脑和颅内腔的基于MR基的体积测量中进行比较。颅内体积（p <.05）和绝对海马（p <.05）和额叶体积（p <.05）显着降低了LCP的个体。在两个认知性能组中，海马和额叶的归一化体积没有差异。 ICV与K-DRS分数相关。用韩国版的DRS测量的LCP个体的一般认知功能在1年或2年的随访认知测试中并未恶化。在教育有限的无数老年人口中，LCP似乎与稳定的智力稳定有关，而不是增加阿尔茨海默氏症痴呆症的风险。 （c）2005 Elsevier Inc.保留所有权利。
Poor cognitive performance of elderly individuals with low educational attainment is often difficult to interpret in dementia evaluation. Lack of education, as well as dementia, is often associated with poor cognitive test performance. To elucidate the underlying structural change of low cognitive performance in elderly individuals with low educational attainment, this study examined the relationship between low cognitive performance (LCP) and brain volumes, especially regions vulnerable to Alzheimer's disease, in nondemented elderly Koreans. Individuals with LCP (n = 14) were matched on age and education with individuals with normal cognitive performance (n = 14). The two groups were compared on the MR-based volumetric measures in the hippocampus, the entorhinal cortex, the amygdala, the temporal lobe, the frontal lobe, the cerebrum, and the intracranial cavity. Intracranial volume (p < .05) and absolute hippocampus (p < .05) and frontal lobe volumes (p < .05) were significantly reduced in individuals with LCP. Normalized volumes of the hippocampus and the frontal lobe did not differ in the two cognitive performance groups. ICV was associated with the K-DRS scores. General cognitive functioning of the LCP individuals, measured with the Korean version of the DRS, did not deteriorate in the 1- or 2-year follow-up cognitive tests. LCP in a nondemented elderly population with limited education appears to be associated with stable lower intelligence rather than increased risk for dementia of the Alzheimer's type. (c) 2005 Elsevier Inc. All rights reserved.