Ceramide induced mitophagy and tumor suppression.
Ceramide induced mitophagy and tumor suppression.
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DOI：
10.1016/j.bbamcr.2014.12.039
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Ogretmen B
中科院分区：
文献类型：
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作者：
Dany M;Ogretmen B
鞘脂是具有生物活性的脂质效应物，参与调节多种细胞信号通路。鞘脂在控制细胞炎症、增殖、死亡、迁移、衰老、转移和自噬等方面发挥着重要作用。鞘脂代谢的改变也与许多人类癌症有关。巨噬（Macroautophagy，简称自噬）是一种通过双膜结构自噬体对胞质物质进行非选择性隔离的形式，对细胞具有保护作用或杀伤作用。神经酰胺是神经鞘脂代谢的中心分子，在不同水平上参与自噬的调节，包括诱导致死性线粒体自噬，这是一种选择性的自噬过程，以靶向和消除受损的线粒体。本文综述了近年来神经酰胺调控细胞自噬尤其是致死性有丝分裂的研究进展，并就神经酰胺调控细胞自噬的作用及机制进行了探讨。
Sphingolipids are bioactive lipid effectors, which are involved in the regulation of various cellular signaling pathways. Sphingolipids play essential roles in controlling cell inflammation, proliferation, death, migration, senescence, metastasis and autophagy. Alterations in sphingolipid metabolism has been also implicated in many human cancers. Macroautophagy (referred to here as autophagy) is a form of nonselective sequestering of cytosolic materials by double membrane structures, autophagosomes, which can be either protective or lethal for cells. Ceramide, a central molecule of sphingolipid metabolism is involved in the regulation of autophagy at various levels, including the induction of lethal mitophagy, a selective autophagy process to target and eliminate damaged mitochondria. In this review, we focused on recent studies with regard to the regulation of autophagy, in particular lethal mitophagy, by ceramide, and aimed at providing discussion points for various context-dependent roles and mechanisms of action of ceramide in controlling mitophagy.