Principles and Applications of Rabbit Models for Atherosclerosis Research.
Principles and Applications of Rabbit Models for Atherosclerosis Research.
复制标题
动脉粥样硬化研究兔模型的原理和应用
DOI：
10.5551/jat.rv17018
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发表时间：
2018-03-01
影响因子：
4.4
通讯作者：
Liang J
中科院分区：
文献类型：
--
作者：
Fan J;Chen Y;Yan H;Niimi M;Wang Y;Liang J
兔子是生物医学研究中最常用的实验动物之一，特别是作为生产抗体的生物反应器。然而，兔子的许多独特特征也使它成为检查人类疾病（如动脉粥样硬化）的许多方面的优秀物种。兔子在系统发育上比啮齿动物更接近人类，除了它们相对合适的大小，温顺的性格，以及在实验室设施中易于使用和维护。由于寿命短，妊娠期短，后代数量多，成本低（与其他大型动物相比）以及基因组学和蛋白质组学的可用性，兔子通常充当小型啮齿动物（小鼠和大鼠）与大型动物（如狗，猪和猴子）之间的桥梁，并在许多转化研究活动中发挥重要作用，例如药物的临床前测试和患者的诊断方法。使用兔子而不是其他动物作为实验模型的原理非常简单：兔子应该用于研究，例如转化研究，这是其他物种难以完成的。最近，兔子的基因组测序和动脉粥样硬化的转录组学分析已经成功完成，这为研究人员未来使用该模型铺平了新的道路。在这篇综述中，我们提供了最近的进展综述，特别是参考兔子在研究人类动脉粥样硬化方面的应用。
Rabbits are one of the most used experimental animals for biomedical research, particularly as a bioreactor for the production of antibodies. However, many unique features of the rabbit have also made it as an excellent species for examining a number of aspects of human diseases such as atherosclerosis. Rabbits are phylogenetically closer to humans than rodents, in addition to their relatively proper size, tame disposition, and ease of use and maintenance in the laboratory facility. Due to their short life spans, short gestation periods, high numbers of progeny, low cost (compared with other large animals) and availability of genomics and proteomics, rabbits usually serve to bridge the gap between smaller rodents (mice and rats) and larger animals, such as dogs, pigs and monkeys, and play an important role in many translational research activities such as pre-clinical testing of drugs and diagnostic methods for patients. The principle of using rabbits rather than other animals as an experimental model is very simple: rabbits should be used for research, such as translational research, that is difficult to accomplish with other species. Recently, rabbit genome sequencing and transcriptomic profiling of atherosclerosis have been successfully completed, which has paved a new way for researchers to use this model in the future. In this review, we provide an overview of the recent progress using rabbits with specific reference to their usefulness for studying human atherosclerosis.