Wild waterfowl migration and domestic duck density shape the epidemiology of highly pathogenic H5N8 influenza in the Republic of Korea.
Wild waterfowl migration and domestic duck density shape the epidemiology of highly pathogenic H5N8 influenza in the Republic of Korea.
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DOI：
10.1016/j.meegid.2015.06.014
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Pybus OG
中科院分区：
文献类型：
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作者：
Hill SC;Lee YJ;Song BM;Kang HM;Lee EK;Hanna A;Gilbert M;Brown IH;Pybus OG
H5N8的系统地理学分析，包括来自韩国的49个新序列。H5N8主要在野鸭和家鸭密集区流动。新的病毒传入韩国发生在野生鸟类迁徙的时候。H5N8流行病学是由野生水禽迁徙和家鸭密度形成的。H5N8可能至少两次进入欧洲，至少三次进入亚洲。高致病性禽流感（HPAI）病毒威胁人类和动物的健康，但他们的出现知之甚少，部分原因是高致病性禽流感亚洲起源的H5N1谱系在1996年发现后立即取样相对稀少。2013年新型H5 N8病毒的发现为更详细地研究HPAI的出现提供了新的机会。在这里，我们调查了H5N8在韩国的起源和传播，韩国是第二个报告新菌株的国家。我们重建病毒的传播，使用地理学方法和解释的家禽密度，越冬野鸟数量和鸟类迁徙模式的生态数据的背景下的结果。研究结果表明，野生水禽迁徙和家鸭密度对H5N8流行具有重要影响。具体而言，我们推断，H5N8通过全北省进入韩国，然后在越冬水禽和家鸭密度较高的西部省份迅速传播，但很少在东部地区持续存在。据估计，大韩民国H5N8的共同祖先是在越冬鸟类向内迁徙的高峰期抵达的。最近的病毒分离可能代表通过鸟类迁徙从尚未采样的水库重新引入。根据大韩民国境外的有限数据，我们的数据表明，H5N8可能至少两次进入欧洲，至少三次进入亚洲，最有可能是由野生候鸟携带的。
Phylogeographic analyses of H5N8, including 49 new sequences from South Korea. H5N8 movement was mostly among areas dense in wild and domestic ducks. New viral introductions to South Korea occurred at time of wild bird migration. H5N8 epidemiology is shaped by wild waterfowl migration and domestic duck density. H5N8 may have entered Europe at least twice, and Asia at least three times. Highly pathogenic avian influenza (HPAI) viruses threaten human and animal health yet their emergence is poorly understood, partly because sampling of the HPAI Asian-origin H5N1 lineage immediately after its identification in 1996 was comparatively sparse. The discovery of a novel H5N8 virus in 2013 provides a new opportunity to investigate HPAI emergence in greater detail. Here we investigate the origin and transmission of H5N8 in the Republic of Korea, the second country to report the new strain. We reconstruct viral spread using phylogeographic methods and interpret the results in the context of ecological data on poultry density, overwintering wild bird numbers, and bird migration patterns. Our results indicate that wild waterfowl migration and domestic duck density were important to H5N8 epidemiology. Specifically, we infer that H5N8 entered the Republic of Korea via Jeonbuk province, then spread rapidly among western provinces where densities of overwintering waterfowl and domestic ducks are higher, yet rarely persisted in eastern regions. The common ancestor of H5N8 in the Republic of Korea was estimated to have arrived during the peak of inward migration of overwintering birds. Recent virus isolations likely represent re-introductions via bird migration from an as-yet unsampled reservoir. Based on the limited data from outside the Republic of Korea, our data suggest that H5N8 may have entered Europe at least twice, and Asia at least three times from this reservoir, most likely carried by wild migrating birds.