Topographical significance of membrane skeletal component protein 4.1B in mammalian organs
Topographical significance of membrane skeletal component protein 4.1B in mammalian organs
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DOI：
10.1111/j.1447-073x.2005.00094.x
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发表时间：
2005-06
影响因子：
1.2
通讯作者：
N. Terada;N. Ohno;H. Yamakawa;O. Ohara;S. Ohno
中科院分区：
文献类型：
--
作者：
N. Terada;N. Ohno;H. Yamakawa;O. Ohara;S. Ohno
上皮细胞的极化结构是细胞结构和功能的基本决定因素。上皮细胞极性的形成和定位是细胞与细胞或细胞与基质粘附、信号转导和细胞骨架相互作用的基础。这些细胞膜结构域通常由一些连接复合物分隔。最近的分子遗传学研究髓鞘和轴突之间的锚结构表明，特定的分子组织极化的轴膜和髓鞘在paranodes，被称为'septate-like junctions'。也有人推测，其他哺乳动物器官可能使用类似的连接系统。蛋白4.1B最初被发现定位于有髓神经纤维的副阳极和副阳极。我们最近对蛋白4.1B的免疫组化研究表明，它在啮齿动物的各种器官中的细胞-细胞和/或细胞-基质粘附中具有重要意义。蛋白质4.1家族的蛋白质被认为具有与细胞粘附、离子平衡、受体应答和信号转导相关的可变分子结构域。因此，更精确地研究蛋白4.1B的分子结构和功能结构域，以及在生理和病理条件下的变化，可能会为各种哺乳动物器官的器官发生提供线索。
The polarized architecture of epithelial cells is a fundamental determinant of cell structures and functions. Both formation and orientation of proper epithelial polarity are needed for cell-cell or cell-matrix adhesion, signal transduction and cytoskeletal interactions of multimolecular complexes at apical, lateral and basal cell membranes. These cell membrane domains are usually segregated by some junctional complexes. Recent molecular genetic studies on the anchor structure between myelin sheaths and axons have indicated the specific molecular organization for polarization of axolemma and the myelin sheaths at paranodes, termed ‘septate-like junctions’. It was also speculated that other mammalian organs may use a similar junctional system. The protein 4.1B was originally found to be localized in paranodes and juxtaparanodes of myelinated nerve fibers. Our recent immunohistochemical studies on protein 4.1B have indicated its significance for the cell-cell and/or cell-matrix adhesion in various rodent organs. The protein 4.1 family of proteins have been supposed to possess variable molecular domains relating to cell adhesion, ion balance, receptor responses and signal transduction. Therefore, more precise studies on the molecular structure and the functional domains of protein 4.1B, as well as on its changes under physiological and pathological conditions, may provide a clue for organogenesis in various mammalian organs.