THE LONG‐ TERM OCULAR AND SYSTEMIC EFFECTS OF TOPICALLY APPLIED METOPROLOL TARTRATE IN GLAUCOMA AND OCULAR HYPERTENSION
THE LONG‐ TERM OCULAR AND SYSTEMIC EFFECTS OF TOPICALLY APPLIED METOPROLOL TARTRATE IN GLAUCOMA AND OCULAR HYPERTENSION
复制标题
局部应用酒石酸美托洛尔治疗青光眼和眼压的长期眼部和全身影响
DOI：
10.1111/j.1755-3768.1981.tb06704.x
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发表时间：
1981
影响因子：
3.4
通讯作者：
G. Krieglstein
中科院分区：
文献类型：
--
作者：
G. Krieglstein
10例高眼压或青光眼患者使用酒石酸美托洛尔（3%）滴眼液治疗4个月以上，每日2次。在整个研究过程中，该药显著降低了所有患者的眼压。平均初始IOP反应相对下降36%，维持IOP下降幅度在23%至30%之间。在治疗的最初几周内，初始反应部分丧失。局部美托洛尔治疗可能影响收缩压和心率。美托洛尔治疗无客观副作用。最常见的主观副作用是灼烧、瘙痒和撕裂。讨论了结果的治疗意义。
Ten patients with ocular hypertension or glaucoma were treated over 4 months with the betablocker Metoprolol tartrate as 3% eye drops twice daily. Intraocular pressures were significantly lowered by the drug in all patients throughout the study. The mean initial IOP response was 36% relative decrease, the maintenance IOP decrease ranged between 23 and 30%. There was partial loss of the initial response within the first weeks of treatment. Topical Metoprolol treatment possibly affects systolic blood pressure and heart rate. There had been no objective side effects of Metoprolol treatment. The most common subjective side effects were burning, itching and tearing. The therapeutic significance of the results is discussed.