RADIORESISTANT TUMOR-CELLS ARE PRESENT IN HEAD AND NECK CARCINOMAS THAT RECUR AFTER RADIOTHERAPY
RADIORESISTANT TUMOR-CELLS ARE PRESENT IN HEAD AND NECK CARCINOMAS THAT RECUR AFTER RADIOTHERAPY
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DOI：
10.1016/0360-3016(88)90297-0
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发表时间：
1988-09-01
影响因子：
7
通讯作者：
DRITSCHILO, A
中科院分区：
文献类型：
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作者：
WEICHSELBAUM, RR;BECKETT, MA;DRITSCHILO, A
我们测定了14个人头颈部鳞状细胞癌肿瘤细胞系的体外生存参数，这些细胞系是从放疗后局部失败的患者中培养出来的。测定的放射生物学参数包括100、200和300 cGy时的.hivin.D、D0、.hivin.n和存活分数。当与从放疗前的头颈癌患者培养的肿瘤细胞、来源于未接受治疗性辐射的患者的人肉瘤细胞系、正常人二倍体成纤维细胞或文献中报道的其他人肿瘤细胞系的体外放射生物学参数相比时，来源于放疗失败的人肿瘤细胞具有放射抗性。
We determined the in vitro survival parameters of 14 human head and neck squamous cell carcinoma tumor cell lines cultured from patients who suffered local failure after a curative course of radiotherapy. The radiobiological parameters determined included .hivin.D, D0, .hivin.n, and surviving fractions at 100, 200, and 300 cGy. When compared to in vitro radiobiological parameters of tumor cells cultured from head and neck cancer patients prior to radiotherapy, human sarcoma cell lines derived from patients not receiving therapeutic radiation, normal human diploid fibroblasts or other human tumor cell lines reported in the literature, the human tumor cells derived from radiotherapy failures are radioresistant.