A statistical model of breast cancer tumour growth with estimation of screening sensitivity as a function of mammographic density
A statistical model of breast cancer tumour growth with estimation of screening sensitivity as a function of mammographic density
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DOI：
10.1177/0962280213492843
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发表时间：
2016-08-01
影响因子：
2.3
通讯作者：
Humphreys, Keith
中科院分区：
文献类型：
--
作者：
Abrahamsson, Linda;Humphreys, Keith
了解筛查敏感性和肿瘤进展对于设计和评估乳腺癌筛查计划非常重要。已经描述了几种估计肿瘤生长速率的方法，其中一些方法同时估计（乳房X线照相术）筛查敏感性。尽管众所周知，连续肿瘤生长建模方法对乳房X线照相筛查敏感性具有深远影响，但没有一种方法包含乳房X线照相密度。我们描述了一种估计乳腺癌肿瘤生长的新方法，该方法建立在最近描述的连续肿瘤生长模型的基础上，并估计乳房X线照相筛查敏感性作为肿瘤大小和乳房X线照相密度的函数。
Understanding screening sensitivity and tumour progression is important for designing and evaluating screening programmes for breast cancer. Several approaches for estimating tumour growth rates have been described, some of which simultaneously estimate (mammography) screening sensitivity. None of the continuous tumour growth modelling approaches has incorporated mammographic density, although it is known to have a profound influence on mammographic screening sensitivity. We describe a new approach for estimating breast cancer tumour growth which builds on recently described continuous tumour growth models and estimates mammographic screening sensitivity as a function of tumour size and mammographic density.