Reduced Visual Evoked Potential Amplitude in Autistic Children with Co-Occurring Features of Attention-Deficit/Hyperactivity Disorder.
Reduced Visual Evoked Potential Amplitude in Autistic Children with Co-Occurring Features of Attention-Deficit/Hyperactivity Disorder.
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具有注意力缺陷/多动障碍共存特征的自闭症儿童视觉诱发电位振幅降低。
DOI：
10.1007/s10803-023-06005-7
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发表时间：
2023
影响因子：
3.9
通讯作者：
Faja,Susan
中科院分区：
文献类型：
--
作者：
Cremone-Caira,Amanda;Braverman,Yael;MacNaughton,GabrielleA;Nikolaeva,JuliaI;Faja,Susan
鉴于自闭症谱系障碍(ASD)和注意力缺陷/多动障碍(ADHD)的特征存在显著重叠，迫切需要确定能够对亚组进行有意义分层的跨诊断标记物。本研究的目的是比较30名自闭症儿童、17名自闭症伴多动症儿童(ASD + ADHD)和21名神经典型儿童(NTC)的视觉诱发电位。当儿童被动地观看模式反转刺激时，记录脑电。从枕中线通道提取P1事件相关电位的平均波幅，并进行组间比较。与ASD和 + 组相比，自闭症ADHD组的P1平均波幅降低，这表明患有ADHD特征的自闭症儿童的大脑活动具有明显的模式。
Provided the significant overlap in features of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), there is a critical need to identify transdiagnostic markers that could meaningfully stratify subgroups. The objective of this study was to compare the visual evoked potential (VEP) between 30 autistic children, 17 autistic children with co-occurring ADHD presentation (ASD + ADHD), and 21 neurotypical children (NTC). Electroencephalography was recorded while children passively viewed a pattern-reversal stimulus. Mean amplitude of the P1 event-related potential was extracted from a midline occipital channel and compared between groups. P1 mean amplitude was reduced in the ASD + ADHD group compared to the ASD and NTC groups, indicating a distinct pattern of brain activity in autistic children with co-occurring ADHD features.