hvps34, an ancient player, enters a growing game: mTOR Complex1l/S6K1 signaling
hvps34, an ancient player, enters a growing game: mTOR Complex1l/S6K1 signaling
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DOI：
10.1016/j.ceb.2007.02.019
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发表时间：
2007-04-01
影响因子：
7.5
通讯作者：
Thomas, George
中科院分区：
文献类型：
--
作者：
Nobukuni, Takahiro;Kozma, Sara C.;Thomas, George
最近的研究表明，mTOR复合物1/S6 K1信号通路的营养输入是由3类PI 3 K或hVps 34介导的，hVps 34是PI 3 K家族最古老的成员。此外，迄今为止的研究表明，在多细胞生物体的进化过程中，该途径的这一古老分支在mTOR复合体1的水平上与生长因子依赖性控制的1类PI 3 K途径合并，以控制生物体的发育和生长。然而，hVps 34也在调节巨自噬中起作用-巨自噬是细胞通过降解细胞内复合物（包括线粒体和核糖体）产生营养物（如氨基酸）的机制。hVps 34的这些功能最初似乎是矛盾的，因为增加的mTOR复合物1激活是由增加的氨基酸水平触发的，而自噬是在细胞面临氨基酸剥夺时触发的。
Recent studies have shown that the nutrient input to the mTOR Complex1/S6K1 signaling pathway is mediated by class 3 PI3K or hVps34, the oldest member of the PI3K family. Moreover, studies to date would suggest that during the evolution of multicellular organisms this ancient branch of the pathway was merged with the growth-factor-hormone-controlled class 1 PI3K pathway at the level of mTOR Complex1 to control the development and growth of the organism. However, hVps34 also plays a role in the regulation of macroautophagy - the mechanism by which cells generate nutrients, such as amino acids, through the degradation of intracellular complexes, including mitochondria and ribosomes. These functions of hVps34 initially appear contradictory, since increased mTOR Complex1 activation is triggered by increased amino acid levels, while autophagy is triggered when cells are faced with amino acid deprivation.