Spontaneous architectural organization of mammalian epidermis from random cell packing
Spontaneous architectural organization of mammalian epidermis from random cell packing
复制标题
DOI：
10.1111/1523-1747.ep12342964
复制
发表时间：
1996-02-01
影响因子：
6.5
通讯作者：
Imayama, S
中科院分区：
文献类型：
--
作者：
Honda, H;Tanemura, M;Imayama, S
某些哺乳动物表皮的角质层细胞以蜂窝状的方式精确地堆叠成柱状。表皮不断失去表面细胞，这些细胞被在迁移到表面期间分化的基底细胞所取代。这种迁移的路径被视为精确定义的细胞柱，这些细胞呈压缩的开尔文四面体形式。我们提出了一个计算机模拟这种建筑组织的基础上的假设，向上迁移的细胞占据不那么拥挤的地区。模拟结果不仅解释了在细胞替换过程中维持该结构的机制，而且还表明该结构是由随机提供的初始细胞自发组织起来的。生物体由不同层次的自组织系统组成;然而，自组织系统主要是在分子水平上研究的。目前的计算机模拟阐明了细胞水平上的自组织系统。
The cells of the stratum corneum in the epidermis of some mammalian species are precisely stacked in columns in a honeycomb fashion. The epidermis constantly loses surface cells, which are replaced by basal cells that have differentiated during migration to the surface, The path of this migration is seen as precisely defined columns of cells that are in compressed Kelvin's tetrakaidecahedral form. We present a computer simulation of this architectural organization based on the assumption that the cells that migrate upward occupy less crowded regions. The simulation not only explained the mechanism by which the architecture is maintained during the process of cell replacement, but also showed that the architecture was spontaneously organized from initial cells supplied at random. Living organisms consist of self-organizing systems at various levels; however, self-organizing systems have been investigated mostly at the molecular level. The present computer simulation clarified the self-organizing system at the cellular level.