Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
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DOI：
10.1016/s0006-3223(01)01269-0
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发表时间：
2002-01-15
影响因子：
10.6
通讯作者：
Childress, AR
中科院分区：
文献类型：
--
作者：
Franklin, TR;Acton, PD;Childress, AR
背景：边缘和前额叶区域的结构性缺陷可能导致可卡因依赖者普遍存在的特征性药物寻求和药物服用行为。迄今为止，尚未对可卡因患者的大脑进行局部结构分析。方法：采用基于体素的形态测量法，结合统计参数映射对可卡因依赖者（n = 13）和可卡因未接触者（n = 16）的磁共振结构图像进行分析，评估两组脑灰质和白质浓度的差异。结果：我们报道，与对照组相比，可卡因患者腹内侧眶额、前扣带、前腹侧岛叶和颞上皮层的灰质浓度降低（p < 0.01，经多次比较校正）。一个区域内灰质浓度的平均下降百分比从5%到11%不等。各组间白质浓度无差异。结论：我们得出的结论是，可卡因患者的大脑在结构上不同于非吸毒对照者。在涉及决策、行为抑制和对环境刺激的情绪效价分配的区域发现了差异，因此，可能导致慢性可卡因使用者的一些行为缺陷特征。生物精神病学2002；[j] 2002中华医学会精神病学分会。
Background: Structural deficiencies within limbic and prefrontal regions may contribute to the characteristic drug-seeking and drug-taking behaviors that prevail in persons dependent on cocaine. To date, a focal structural analysis of the brains of cocaine patients has not been undertaken.Methods: We used voxel based morphometry in conj. unction with statistical parametric mapping on the structural magnetic resonance images of cocaine-dependent (n = 13) and cocaine-naive individuals (n = 16) to assess differences between the two groups in gray and white matter concentration.Results: We report a decrease in gray matter concentration in the ventromedial orbitofrontal, anterior cingulate, anteroventral insular, and superior temporal cortices of cocaine patients in comparison to controls (p < .01 corrected for multiple comparisons). The average percentage decrease in gray matter concentration within a region ranged from 5% to 11%. White matter concentration did not differ between groups.Conclusions: We conclude that the brains of cocaine patients are structurally dissimilar from those of nondrug-using controls. The differences were detected in regions involved in decision-making, behavioral inhibition and assignation of emotional valence to environmental stimuli and, hence, may contribute to some of the behavioral deficits characteristic of chronic cocaine users. Biol Psychiatry 2002;51:134-142 (C) 2002 Society of Biological Psychiatry.