AVERMECTINS, NEW FAMILY OF POTENT ANTHELMINTIC AGENTS - PRODUCING ORGANISM AND FERMENTATION
AVERMECTINS, NEW FAMILY OF POTENT ANTHELMINTIC AGENTS - PRODUCING ORGANISM AND FERMENTATION
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DOI：
10.1128/aac.15.3.361
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发表时间：
1979-01-01
影响因子：
4.9
通讯作者：
OMURA, S
中科院分区：
文献类型：
--
作者：
BURG, RW;MILLER, BM;OMURA, S
阿维菌素是一种化学上相关的药物的复合物，具有非常强的驱虫活性。它们是由一种新的放线菌NRRL 8165，阿维链霉菌产生的。描述了区分生产生物与其他物种的形态和文化特征。阿维菌素是一系列大环内酯类抗生素衍生物，与大环内酯类或多烯类抗生素相比，缺乏显著的抗菌或抗真菌活性。当以0.0002%的饲料喂养感染小鼠6天时，阿维菌素复合物对胃肠道线虫Nematospiroides pneumonus具有完全活性。发酵开发，包括培养基改良和菌株选择，导致发酵液产率从9-500 μ g/ml增加。
The avermectins are a complex of chemically related agents which exhibit extraordinarily potent anthelmintic activity. They are produced by a novel species of actinomycete, NRRL 8165, Streptomyces avermitilis. The morphological and cultural characteristics which differentiate the producing organism from other species are described. The avermectins were identified as a series of macrocyclic lactone derivatives which, in contrast to the macrolide or polyene antibiotics, lack significant antibacterial or antifungal activity. The avermectin complex is fully active against the gastrointestinal nematode Nematospiroides dubius, when fed to infected mice for 6 days at 0.0002% of the diet. Fermentation development, including medium modification and strain selection, resulted in increasing the broth yields from 9-500 .mu.g/ml.