Phase response analyses support a relaxation oscillator model of locomotor rhythm generation in Caenorhabditis elegans.
Phase response analyses support a relaxation oscillator model of locomotor rhythm generation in Caenorhabditis elegans.
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DOI：
10.7554/elife.69905
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发表时间：
2021-09-27
期刊：
影响因子：
7.7
通讯作者：
Fang-Yen C
中科院分区：
文献类型：
--
作者：
Ji H;Fouad AD;Teng S;Liu A;Alvarez-Illera P;Yao B;Li Z;Fang-Yen C
神经回路与肌肉和感觉反馈协调，以产生适合动物环境的运动行为。In C.然而，在线虫中，运动回路产生波动并根据环境调节它们的机制在很大程度上尚不清楚。对C. elegans运动过程中的自由运动和短暂的光遗传肌肉抑制。波动运动是高度不对称的弯曲和不弯曲的持续时间在每个周期。由头部肌肉的短暂光遗传学抑制诱导的相位响应曲线显示出作为施加扰动的相位的函数的逐渐增加和快速减少。开发了一种基于本体感受阈值的弛张振荡器模型，该模型可以切换主动肌肉力矩，并且显示出与自由运动，相位响应和以前的步态适应机械负荷的结果的数据定量一致。我们的研究结果表明，C。elegans运动模式生成在紧凑的电路内。
Neural circuits coordinate with muscles and sensory feedback to generate motor behaviors appropriate to an animal’s environment. In C. elegans, the mechanisms by which the motor circuit generates undulations and modulates them based on the environment are largely unclear. We quantitatively analyzed C. elegans locomotion during free movement and during transient optogenetic muscle inhibition. Undulatory movements were highly asymmetrical with respect to the duration of bending and unbending during each cycle. Phase response curves induced by brief optogenetic inhibition of head muscles showed gradual increases and rapid decreases as a function of phase at which the perturbation was applied. A relaxation oscillator model based on proprioceptive thresholds that switch the active muscle moment was developed and is shown to quantitatively agree with data from free movement, phase responses, and previous results for gait adaptation to mechanical loadings. Our results suggest a neuromuscular mechanism underlying C. elegans motor pattern generation within a compact circuit.