Methoprene photolytic compounds disrupt zebrafish development, producing phenocopies of mutants in the sonic hedgehog signaling pathway
Methoprene photolytic compounds disrupt zebrafish development, producing phenocopies of mutants in the sonic hedgehog signaling pathway
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DOI：
10.1007/s10126-002-0062-5
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发表时间：
2003-03-01
影响因子：
3
通讯作者：
McCarthy, RA
中科院分区：
文献类型：
--
作者：
Smith, GD;Wilburn, C;McCarthy, RA
环境化学物质被认为会影响内分泌或类维生素A途径，导致人类和其他脊椎动物发育异常。现有的证据表明，斑马鱼胚胎暴露于阳光诱导的农药甲虫酯的光解产物中会导致头部、心脏、胸鳍和体节以及脊髓运动和视神经轴突的发育缺陷。暴露的胚胎是斑马鱼 you 型突变体的表型，并且与突变体 sonic-you 一样，显示出信号蛋白 sonic hedgehog 的表达不足。在用视黄酸合成抑制剂柠檬醛处理的胚胎中也显示出音猬因子表达的减少。这项研究将柠檬醛相关化合物确定为具有潜在环境问题的胚胎信号干扰物。
Environmental chemicals have been proposed to impact endocrine or retinoid pathways, causing developmental abnormalities in humans and other vertebrates. Presented evidence shows that exposure of zebrafish embryos to sunlight-induced photolytic products of the pesticide methoprene results in developmental defects in the head, heart, pectoral fins, and somites, and in spinal motor and optic nerve axons. Exposed embryos are phenocopies of zebrafish you-type mutants and, as in the mutant sonic-you, show underexpression of the signaling protein sonic hedgehog. Reduced expression of sonic hedgehog is also displayed in embryos treated with the retinoic acid synthesis inhibitor citral. This study identifies citral-related compounds as embryonic signaling disruptors of potential environmental concern.