Interleukin-5 transgenic mice show enhanced resistance to primary infections with Nippostrongylus brasiliensis but not primary infections with Toxocara canis
Interleukin-5 transgenic mice show enhanced resistance to primary infections with Nippostrongylus brasiliensis but not primary infections with Toxocara canis
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DOI：
10.1128/iai.67.2.989-993.1999
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发表时间：
1999-02-01
影响因子：
3.1
通讯作者：
Parsons, JC
中科院分区：
文献类型：
--
作者：
Dent, LA;Daly, CM;Parsons, JC
在这项研究中，白介素5(IL-5)转基因终生嗜酸性粒细胞增多症小鼠对两种组织入侵线虫--巴西尼波氏线虫和犬弓形虫的初次感染的抵抗力进行了评估。与非转基因小鼠相比，三个不同程度嗜酸性粒细胞增多症的IL-5转基因小鼠均表现出对巴氏新城疫的增强抗性。尽管转基因和非转基因宿主的最终驱虫时间相似，但转基因小鼠的肠道蠕虫在整个感染过程中数量较少，在感染过程中尺寸没有增加，繁殖力也要低得多。相反，犬旋毛虫幼虫从具有“低”或“高”嗜酸性的转基因小鼠的组织和从非转基因小鼠的组织中恢复的数量相似。这些结果和其他数据表明，嗜酸性粒细胞可能有助于宿主对某些寄生虫的抵抗力。寄生虫通过宿主的时间可能与对嗜酸性粒细胞的相对敏感性有关。
In this study, interleukin-5 (IL-5) transgenic mice with lifelong eosinophilia were assessed for resistance to primary infections with two tissue-invading nematodes, Nippostrongylus brasiliensis and Toxocara canis. Relative to nontransgenic littermates, three lines of IL-5 transgenic mice with varying degrees of eosinophilia all displayed enhanced resistance to N. brasiliensis. Although the timing of final worm expulsion was similar in transgenic and nontransgenic hosts, intestinal worms in transgenic mice were fewer in number throughout infection, failed to increase in size over the course of the infection, and were much less fecund. In contrast, T. canis larvae were recovered in similar numbers from tissues of transgenic mice with "low" or "high" eosinophilia and from nontransgenic mice. These results and other data suggest that eosinophils can contribute to host resistance to some parasite species. Parasite transit time through the host may correlate with relative sensitivity to eosinophils.