Increased risk of depressive disorder following diagnosis with bladder pain syndrome/interstitial cystitis
Increased risk of depressive disorder following diagnosis with bladder pain syndrome/interstitial cystitis
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DOI：
10.1002/nau.22316
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发表时间：
2013-06-01
影响因子：
2
通讯作者：
Lin, Herng-Ching
中科院分区：
文献类型：
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作者：
Keller, Joseph J.;Liu, Shih-Ping;Lin, Herng-Ching
膀胱疼痛综合征/间质性膀胱炎 (BPS/IC) 是一种病因不明的慢性疼痛综合征，主要影响女性。本研究采用纵向随访设计，旨在检查患有 BPS/IC 的女性与一般人群在诊断后 1 年内患抑郁症 (DD) 的风险。方法本研究使用台湾纵向健康保险数据库的数据。研究组共纳入 832 名 BPS/IC 患者，4,160 名匹配的非 BPS/IC 参与者作为对照组。对每位患者 (n=4,992) 进行为期 1 年的单独跟踪，以确定随后被诊断为 DD 的患者。 Cox 比例风险回归（按年龄组和指数年份分层）用于估计 BPS/IC 诊断后后续 DD 的风险。结果我们发现，在 1 年随访期间，BPS/IC 患者的 DD 发生率为每 100 人年 4.69 例（95% CI：3.38-6.34），对照患者为每 100 人年 0.94 例（95% CI：0.68-1.27）。 BPS/IC 患者 1 年随访期间发生 DD 的风险比 (HR) 为 5.06 (95% CI: 3.21-7.96，P
Aim Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic pain syndrome of unknown etiology that primarily affects women. Using a longitudinal follow-up design, this study aimed to examine the risk of depressive disorder (DD) among women with BPS/IC compared to the general population during a 1-year period following their diagnosis. Method This study used data from the Taiwan Longitudinal Health Insurance Database. A total of 832 patients with BPS/IC were included in the study group and 4,160 matched non-BPS/IC enrollees were included as the comparison group. Each patient (n=4,992) was individually tracked for a 1-year period to identify those who subsequently received a diagnosis of DD. Cox proportional hazards regressions (stratified by age group and the index year) were used to estimate the risk of subsequent DD following a diagnosis of BPS/IC. Results We found that during the 1-year follow-up, the incidence rate of DD was 4.69 (95% CI: 3.38-6.34) per 100 person-years in patients with BPS/IC and 0.94 (95% CI: 0.68-1.27) per 100 person-years in comparison patients. The hazard ratio (HR) of DD during the 1-year follow-up period for patients with BPS/IC was 5.06 (95% CI: 3.21-7.96, P