A CUPRIC SILVER METHOD FOR IMPREGNATION OF TERMINAL AXON DEGENERATION AND ITS FURTHER USE IN STAINING GRANULAR ARGYROPHILIC NEURONS
A CUPRIC SILVER METHOD FOR IMPREGNATION OF TERMINAL AXON DEGENERATION AND ITS FURTHER USE IN STAINING GRANULAR ARGYROPHILIC NEURONS
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DOI：
10.1159/000125825
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发表时间：
1969-01-01
影响因子：
1.7
通讯作者：
DEOLMOS, JS
中科院分区：
文献类型：
--
作者：
DEOLMOS, JS
The development and perfection of the Nauta-Gygax [65] and Fink-Heimer [28] techniques, which stain degenerating nerve fibers with a high degree of selectivity, has been followed with great interest by neuroanatomists and other experimental neurologists. The Fink-Heimer techniques are especially valuable because they reveal the finest ramifications of degenerating fibers and the position of degenerating synaptic knobs. The techniques are applied to sections of brain and spinal cord from experimental animals in which neurological lesions have been intentionally inflicted and which have been allowed to survive the surgery long enough to permit adequate accumulation of degeneration products. The typical result of axotomy is degeneration of the axon and myelin sheath distal to the lesion. The degeneration occurs throughout the length of the severed axon and involves the synaptic knobs. When serial sections are stained and examined it is possible to discover, by reconstruction, the paths and terminal distribution of the axons involved by the lesion. Acceptance of the Fink-Heimer technique for degenerating axoplasm will be undoubtedly followed by great advances in neuroanatomical science as was general acceptance of the Nauta-Gygax technique over a decade ago. Despite the widespread use of the Nauta-Gygax technique and the ever growing acceptance of the Fink-Heimer technique, little is known about
