Regeneration of periodontal bone defects with dental pulp stem cells grafting: Systematic Review.
Regeneration of periodontal bone defects with dental pulp stem cells grafting: Systematic Review.
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DOI：
10.4317/jced.55574
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发表时间：
2019-04-01
影响因子：
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通讯作者：
Sanchez-Garces, M Angeles
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文献类型：
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作者：
Amghar-Maach, Sara;Gay-Escoda, Cosme;Sanchez-Garces, M Angeles
研究背景：探讨牙髓干细胞（DPSC）在牙周缺损中修复牙周组织的最佳方法。许多程序已经做了促进牙周再生。骨移植物在临床和影像学上表现良好，但组织学上似乎具有最小的骨诱导能力。在减少探查深度和增加插入量方面，另一种超越传统手术的选择是引导组织再生和组织工程，这可能是帮助再生活功能骨和牙周结构的另一种方法。材料与方法：在Cochrane、PubMed-MEDLINE和Scopus数据库中检索关键词：“牙髓干细胞”、“牙周再生”、“引导组织再生，牙周”、“组织再生”、“牙周骨缺损”、“牙周组织工程”和“牙周缺损”。纳入标准为英文文章，最长为10年，其中DPSC用于牙周缺损的再生。排除标准是非英文发表的研究、病例报告、病例系列、文献综述以及拔牙引起牙周缺损的研究。结果：共纳入185篇文献，剔除重复文献101篇，其中94篇在阅读标题和摘要时被丢弃。获得7篇文章供全文阅读：一篇病例报告和一个病例系列被删除。系统评价是通过5个动物体内试验研究进行的。与注射相比，DPSC片再生的骨量更大。若添加肝细胞生长因子（HGF），最大骨再生体积为69.3±3.9 mm3
BACKGROUND: The main objective is to evaluate the way to graft the dental pulp stem cells (DPSC) in periodontal defects that best regenerate periodontal tissues. Numerous procedures have been done to promote periodontal regeneration. Bone grafts show good gains clinically and radiographically but histologically seem to have minimal osteoinductive capacity. Another option that exceeds conventional surgery in reducing probing depth and increasing insertion is guided tissue regeneration and tissue engineering that could be an alternative approach to help in the regeneration of living functional bone and peri-dental structures.MATERIAL AND METHODS: A search was carried out in Cochrane, PubMed-MEDLINE and Scopus databases with keywords: "dental pulp stem cells", "periodontal regeneration", "guided tissue regeneration, periodontal", "tissue regeneration", "periodontal bone defects", "periodontal tissue engineering" and "periodontal defect". Inclusion criteria were articles in English, maximum 10 years old, in which DPSC were used to regenerate a periodontal defect. Exclusion criteria were studies not published in English, case reports, case series, literature reviews, and studies in which periodontal defect was caused by dental extraction.RESULTS: Out of the 185 articles identified, 101 after excluding duplicates, of which 94 were discarded when reading the title and abstract. 7 articles were obtained for the full text reading: a case report and a case series were eliminated. The systematic review is performed with 5 animal testing studies in vivo. The DPSC sheets regenerate a greater amount of bone than the injection. If HGF (hepatocyte growth factor) is added, the maximum bone volume regenerated (69.3 ± 3.9 mm3; p