Insulin-Like Growth Factor-I, Physical Activity, and Control of Cellular Anabolism
Insulin-Like Growth Factor-I, Physical Activity, and Control of Cellular Anabolism
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DOI：
10.1249/mss.0b013e3181b07c39
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发表时间：
2010-01-01
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通讯作者：
Nindl, Bradley C.
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作者：
Nindl, Bradley C.
B.宁德尔C.胰岛素样生长因子-I、体力活动和细胞抑制的控制。医学科学体育锻炼：第42卷，第1期，第100页。35-38，2010年。负责介导运动有益结果的潜在机制无疑是许多，但胰岛素样生长因子-I（IGF-I）系统正在成为一个重要的和中央激素轴，在细胞凋亡方面发挥着重要作用。这篇介绍性的文章总结了2008年美国运动医学学会全国研讨会的一部分，题为“胰岛素样生长因子-I，身体活动和细胞抑制的控制”的论文的意图和内容。个人作者和他们的论文如下：Jan Frystyk撰写“运动与生长激素/胰岛素样生长因子-I轴之间的关系”，Greg亚当斯撰写“骨骼肌中的IGF-I信号传导和细胞因子相互作用的潜力”，布拉德Nindl撰写“胰岛素样生长因子-I作为健康，健身和训练状态的生物标志物”。“这些论文集中在1）运动研究范式内IGF-I的不同测定方法，2）研究表明与几种促炎细胞因子相关的细胞内信号传导组分具有与骨骼肌中的合成代谢信号传导过程相互作用的潜力，以及3）IGF-I作为与运动训练、肌肉和骨骼重塑、身体组成、认知相关的生物标志物的概述，和癌症总之，这些论文的贡献无疑将引起人们对IGF-I系统巨大的调控复杂性的关注，并有望说服读者，IGF-I系统需要进一步详细的科学调查，以解决许多悬而未决的问题和矛盾的实验结果。IGF-I系统仍然是人类生理学中最有趣和最迷人的奇迹之一，似乎是调节身体活动的许多适应的中心。
NINDL, B. C. Insulin-Like Growth Factor-I, Physical Activity, and Control of Cellular Anabolism. Med. Sci. Sports Exerc., Vol. 42, No. 1, pp. 35-38, 2010. The underlying mechanisms responsible for mediating the beneficial outcomes of exercise undoubtedly are many, but the insulin-like growth factor-I (IGF-I) system is emerging as an important and central hormonal axis that plays a significant role concerning cellular anabolism. This introductory article summarizes the intent and the content for papers presented as part of a 2008 American College of Sports Medicine national symposium entitled "Insulin-like Growth Factor-I, Physical Activity, and Control of Cellular Anabolism." The individual authors and their papers are as follows: Jan Frystyk authoring "The relationship between exercise and the growth hormone/insulin-like growth factor-I axis," Greg Adams authoring "IGF-I signaling in skeletal muscle and the potential for cytokine interactions," and Brad Nindl authoring "Insulin-like growth factor-I as a biomarker of health, fitness, and training status." These papers focus on 1) different assay methodologies for IGF-I within the paradigm of exercise studies, 2) research demonstrating that intracellular signaling components associated with several proinflammatory cytokines have the potential to interact with anabolic signaling processes in skeletal muscle, and 3) an overview of IGF-I as a biomarker related to exercise training, Muscle and bone remodeling, body composition, cognition, and cancer. When summed in total, the contribution that these papers will make will undoubtedly involve bringing attention to the vast regulatory complexity of the IGF-I system and will hopefully convince the reader that the IGF-I system warrants further detailed scientific inquiry to resolve many unanswered questions and paradoxical experimental findings. The IGF-I system remains one of the most intriguing and captivating marvels of human physiology that seems central in mediating numerous adaptations from physical activity.