Mastication influences the survival of newly generated cells in mouse dentate gyrus
Mastication influences the survival of newly generated cells in mouse dentate gyrus
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DOI：
10.1097/00001756-200502280-00009
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发表时间：
2005-02
期刊：
影响因子：
1.7
通讯作者：
M. Mitome;T. Hasegawa;T. Shirakawa
中科院分区：
文献类型：
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作者：
M. Mitome;T. Hasegawa;T. Shirakawa
我们研究了软食和牙齿脱落对成人齿状回神经发生的影响。 4 周大的小鼠在去除或不去除臼齿的情况下接受粉末饮食 10 周。他们在 14 周龄时每天注射溴脱氧尿苷 (BrdU)，连续 12 天。最后一次注射 BrdU 后 1 天，这些小鼠齿状回中的 BrdU 阳性细胞数量与对照小鼠没有差异。然而，在注射 BrdU 后 5 周，这些小鼠中的 BrdU 阳性细胞数量比对照组显示出更大的减少，并且无磨牙小鼠中神经元与 BrdU 阳性细胞的比率下降。这些结果表明咀嚼影响成年齿状回中新生成的细胞的存活。
We examined the effects of soft food and tooth loss on neurogenesis in the adult dentate gyrus. Four-week-old mice were subjected to a powder diet for 10 weeks with or without removal of molars. They received a daily injection of bromodeoxyuridine (BrdU) at 14 weeks of age for 12 consecutive days. The number of BrdU-positive cells in the dentate gyrus of these mice did not differ from that of control at 1 day after the last BrdU injection. However, the BrdU-positive cells in these mice showed a larger reduction in number than in control at 5 weeks after the BrdU injection and the ratio of neurons to BrdU-positive cells decreased in the molarless mice. These results suggest that mastication influences the survival of newly generated cells in the adult dentate gyrus.