Divergent syntheses of 2-aminonicotinonitriles and pyrazolines by copper-catalyzed cyclization of oxime ester.
Divergent syntheses of 2-aminonicotinonitriles and pyrazolines by copper-catalyzed cyclization of oxime ester.
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DOI：
10.1021/ol500094w
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发表时间：
2014-02
期刊：
影响因子：
5.2
通讯作者：
Qifan Wu;Yan Zhang;Sunliang Cui
中科院分区：
文献类型：
--
作者：
Qifan Wu;Yan Zhang;Sunliang Cui
报道了铜催化肟酯环化反应合成发散杂环的研究。肟酯作为烯胺前体与丙二腈和醛在一锅反应中环化以获得2-氨基烟腈，而与N-磺酰亚胺环化导致吡唑啉的合成。
Copper-catalyzed cyclization of an oxime ester toward divergent heterocycle synthesis is reported. Oxime ester serves as an enamine precursor to cyclize with malononitrile and aldehydes for access to 2-aminonicotinonitriles in a one-pot reaction, while cyclizing with N-sulfonylimines leads to synthesis of pyrazolines.