The burden of sleep disordered breathing in infants with Down syndrome referred to tertiary sleep center.
The burden of sleep disordered breathing in infants with Down syndrome referred to tertiary sleep center.
复制标题
唐氏综合症婴儿睡眠呼吸障碍的负担转交给三级睡眠中心。
DOI：
10.1002/ppul.26302
复制
发表时间：
2023
影响因子：
3.1
通讯作者：
DelRosso,LourdesM
中科院分区：
文献类型：
--
作者：
Cho,Yeilim;Kwon,Younghoon;Ruth,Chris;Cheng,Samuel;DelRosso,LourdesM
前言唐氏综合征（Down Syndrome，DS）儿童是睡眠呼吸障碍（Sleep Disordered Breathing，SDB）的高危人群。我们的目的是研究的负担SDB的婴儿与DS提到三级sleep center.MethodsInfants（≤12个月大）与DS谁进行连续多导睡眠图（PSG）在一个单一的学术睡眠中心超过6年的时间被包括在内。阻塞性睡眠呼吸暂停（OSA）（阻塞性呼吸暂停低通气指数[oAHI]>1/hr）、中枢性睡眠呼吸暂停（中枢性呼吸暂停指数> 5/h）和通气不足（潮气末或经皮CO2> 50 mmHg的时间占总睡眠时间的25%）和低氧血症（O2饱和度> <88% >5 min的时间）的存在被确定。PSG包括诊断性（n= 13）和分段夜间（n= 27，68%）研究。所有患者均符合OSA标准，平均oAHI为34.6/h（32.3）。中枢性睡眠呼吸暂停11例（27.5%）。共有11例（27.5%）出现低氧血症。通气不足是目前在10（25%）infants.ConclusionThis study突出了SDB的高患病率与DS婴儿提到的睡眠中心，并支持在这个病人群体的早期PSG评估。
IntroductionChildren with Down Syndrome (DS) are at high risk of sleep disordered breathing (SDB). We aimed to examine the burden of SDB in infants with DS referred to tertiary sleep center.MethodsInfants (≤12 months old) with DS who underwent consecutive polysomnography (PSG) at a single academic sleep center over a 6‐year period were included. obstructive sleep apnea (OSA) (obstructive apnea hypopnea index [oAHI]>1/hr), central sleep apnea (central apnea index > 5/h) and the presence of hypoventilation (% time spent with CO2> 50 mmHg either by end‐tidal or transcutaneous> 25% of total sleep time) and hypoxemia (time spent with O2saturation <88% >5 min) were ascertained.ResultsA total of 40 infants were included (Mean age 6.6 months, male 66%). PSGs consisted of diagnostic (n= 13) and split night (n= 27, 68%) studies. All met criteria for OSA with mean oAHI 34.6/h (32.3). Central sleep apnea was present in 11 (27.5%) of infants. A total of 11 (27.5%) had hypoxemia. Hypoventilation was present in 10 (25%) infants.ConclusionThis study highlights the high prevalence of SDB in infants with DS referred to a sleep center, and supports early PSG assessment in this patient population.