Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review
Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review
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氨基吡啶的合成、络合和生物活性：小综述
DOI：
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
R. Ngochindo
中科院分区：
文献类型：
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作者：
kingsley John Orie;R. Duru;R. Ngochindo
氨基吡啶类化合物是近几十年来被广泛研究的一类杂环化合物，因其具有有趣的生物活性而受到广泛研究。它们以三种异构体形式存在：2-氨基吡啶、3-氨基吡啶和4-氨基吡啶。它们药理活性的多样性吸引了许多研究人员的注意，以探索它们具有广泛潜力的原因。本文通过系统的文献综述和含量分析，综述了不同类型氨基吡啶衍生物的有效合成方法及其与金属的配位和生物活性等方面的最新进展。讨论了氨基吡啶的其他重要概念：碱性、与异构体百分率相关的电势以及表征氨基吡啶的光谱更新。这项研究的结果还揭示了用于提纯过程的一系列溶剂；关于尚未用于合成氨基吡啶衍生物的异构体及其各自的生物活性的想法。本研究的意义在于揭示了多种合成方法，这可能有助于开发具有较高生物活性和较低毒性的新型氨基吡啶类化合物。
Aminopyridines are among the classes of heterocyclic compounds that have been extensively studied in the last few decades owing to their interesting biological activities. They exist in three isomeric forms: 2-aminopyridine, 3-aminopyridine and 4-aminopyridine. The diversity in their pharmacological activities has attracted the attention of many researchers to explore the reasons for their wide potential. This study examines recent advances related to the efficient procedure for synthesizing different types of aminopyridine derivatives, its coordination site with metals and biological activities using systematic literature review and content analysis. Other important concepts of aminopyridines discussed are basicity, electric hindrance as related to percentage yield of isomeric forms and spectra updates on the characterization of aminopyridines. The findings from this study also reveal the array of solvents used for purification processes; ideas on isomers that have not been used in the synthesis of aminopyridine derivatives and their respective biological activities. The significance of this study is on the various synthetic methods revealed, which may be helpful to the development of newer compounds with aminopyridines moieties that could offer high bioactivity and lesser toxicity.