Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses.
Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses.
复制标题
乙醇对选定脑区 NMDA 诱发的电生理活动的抑制：乙醇敏感和乙醇不敏感的 NMDA 诱发反应的证据。
DOI：
10.1016/0006-8993(93)91483-9
复制
发表时间：
1993
期刊：
影响因子：
2.9
通讯作者：
Breese,GR
中科院分区：
文献类型：
--
作者：
Simson,PE;Criswell,HE;Breese,GR
我们的实验室先前已经表明，全身给予乙醇抑制NMDA诱发的电生理活动，在一些，但不是全部，在内侧隔神经元。在本报告中，有人发现，乙醇，通过电渗局部应用时，有效地抑制NMDA诱发的神经元活动的电流依赖性的方式在下丘和海马。相反，局部应用乙醇未能抑制侧隔中NMDA诱发的活动。乙醇对下丘NMDA诱发活动的抑制是特异性的，因为乙醇不能抑制兴奋性神经递质谷氨酸诱发的下丘神经元活动。这些发现表明，乙醇可以通过局部作用特异性地抑制体内NMDA诱发的活动，并且乙醇抑制NMDA诱发的活动的能力在脑中区域性地变化。这些结果被解释的可能性，存在两种类型的NMDA受体，一种对乙醇敏感，其他对乙醇不敏感，进行了讨论。
Our laboratory has previously shown that systemically administered ethanol inhibits NMDA-evoked electrophysiological activity in some, but not all, neurons in the medial septum. In the present report, it was found that ethanol, when applied locally via electro-osmosis, potently inhibited NMDA-evoked neuronal activity in a current-dependent manner in the inferior colliculus and hippocampus. In contrast, locally applied ethanol failed to inhibit NMDA-evoked activity in the lateral septum. The inhibition by ethanol of NMDA-evoked activity in the inferior colliculus was specific, in that ethanol failed to inhibit neuronal activity of the inferior colliculus evoked by the excitatory neurotransmitter glutamate. These findings indicate that ethanol can specifically inhibit NMDA-evoked activity in vivo via a local action, and that the ability of ethanol to inhibit NMDA-evoked activity varies regionally in brain. The possibility that these results are explained by the existence of two types of NMDA receptors, one sensitive to ethanol, the other insensitive to ethanol, is discussed.